Protein Alignment dbo and KLHL15

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_085127.2
• Gene: KLHL15 / 80311
• HGNCID: 29347
• Length: 604
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 156/560 - (27%)
• Similarity: 254/560 - (45%)
• Gaps: 62/560 - (11%)

  Fly    71 LCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHI 135
            |.||.|.:...:..||:.:|:..|.||..|||.::.|..|.::.::.:.......::.|.|...|
Human    30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTI 94

  Fly   136 IVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFAD-----THSCRELLRIADK 195
            .:..:.|..:|.||..:||:|:...||.||..::...||..|....|     ....||.|   |.
Human    95 ELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKL---DT 156

  Fly   196 FTQHNFQEVMESEEFL-LLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQ 259
            |...||..:|...:|| .|...:|:..:.:|.|:...|.:::.||.|||::: ..|.:|...::|
Human   157 FLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHD-RRRWRHTDTIIQ 220

  Fly   260 HVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPL--MQGPRTRPRKPTR--- 319
            ::|..|::|..:...|.:....|.....|..||:|.||.....::||  |:..|.|..||..
Human   221 NIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVF 285

  Fly   320 RGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRR--CGVGVAVLNDLLYAVGGH----D 378
            ||    .:|.......|..:::  |:. .|::..|....|  |   :|::|:.::.:||.    |
Human   286 RG----MIGHSMVNSKILLLKK--PRV-WWELEGPQVPLRPDC---LAIVNNFVFLLGGEELGPD 340

  Fly   379 GQSYLNS-IERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKEN 442
            |:.:.:| :.||||:.|.| ..:|..:..|:...|.|:..|:|||.|:...:.....||||...:
Human   341 GEFHASSKVFRYDPRQNSW-LQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITND 404

  Fly   443 KWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRH---------------NKWV 492
            ||..|.|....:.|....||...|:..||.........|..:||..               |.|.
Human   405 KWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWE 469

  Fly   493 AVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMEL---------SSAERYNPLTNTWSPIVAMTSRR 548
            ..|.|:..|.......:|..:|..||  .|:.|         .|.|.|||.|:.|:.:.:|...|
Human   470 NKSKMNYARCFHKMISYNGKLYVFGG--VCVILRASFESQGCPSTEVYNPETDQWTILASMPIGR 532

  Fly   549 SGVGLAVVNGQLYAVGG--FDGSAYLKTIEVYDPETNQWR 586
            ||.|:.|::.|:..:||  ::|. |..:|..:||:.|:|:
Human   533 SGHGVTVLDKQIMVLGGLCYNGH-YSDSILTFDPDENKWK 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	31/104 (30%)
		PHA03098	69..587	CDD:222983	156/560 (28%)
		KELCH repeat	359..403	CDD:276965	16/50 (32%)
		KELCH repeat	407..451	CDD:276965	16/43 (37%)
		KELCH repeat	454..497	CDD:276965	12/57 (21%)
		KELCH repeat	501..545	CDD:276965	14/52 (27%)
		KELCH repeat	548..593	CDD:276965	15/41 (37%)
KLHL15	NP_085127.2	BTB_POZ_KLHL15	1..137	CDD:349553	31/106 (29%)
		PHA03098	33..576	CDD:222983	154/557 (28%)
		BACK_KLHL15	128..235	CDD:350529	30/110 (27%)
		KELCH repeat	321..365	CDD:276965	15/47 (32%)
		Kelch 1	328..379		15/51 (29%)
		KELCH repeat	369..412	CDD:276965	15/42 (36%)
		Kelch 2	381..426		15/44 (34%)
		KELCH repeat	417..474	CDD:276965	12/56 (21%)
		Kelch 3	428..473		8/44 (18%)
		KELCH repeat	478..529	CDD:276965	14/52 (27%)
		Kelch 4	489..542		18/54 (33%)
		KELCH repeat	532..572	CDD:276965	15/41 (37%)
		Kelch 5	544..590		9/29 (31%)