DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and Klhl2

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_017168500.1	Gene:	Klhl2 / 77113	MGIID:	1924363	Length:	626	Species:	Mus musculus

Alignment Length:	622	Identity:	259/622 - (41%)
Similarity:	361/622 - (58%)	Gaps:	59/622 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PPSPARLSH---------TSEKHPKVTLTE---------LNMLRRHRELCDVVLNVGGRKIFAHR 87
            ||:..:..|         ..|||..:|:..         :|.||....||||.:.....:|.|||
Mouse     7 PPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHR 71

  Fly    88 VILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNV---------- 142
            |:|:|||.||.||||||:.|||...|.|:::|...:.:|:|:.|||.|.|.|.||
Mouse    72 VVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVQCKSLHRG 136

  Fly   143 -----------------------QTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTH 184
                                   |.|||||.||||.:::..|||||:.||.|.||||||||||.|
Mouse   137 WKNRKESKTTSGRPSGVSYSLYEQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 201

  Fly   185 SCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAE 249
            :|.:||..|:.:.:.:|.:|:.|||||.|.:.|:..:|.||:|.:.|||:||.||::|:.::...
Mouse   202 ACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV 266

  Fly   250 RRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLP-QERPLMQGPRTR 313
            |::.:|::::|||||||..::||..|..:.||::..||:|.:.||..|.||| ::|.||:..|||
Mouse   267 RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTR 331

  Fly   314 PRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHD 378
            .|.|....:::..|||. :..||.|||.:|.:...|..||.:..|||..|:..:..|::||||.:
Mouse   332 LRTPMNLPKLMVVVGGQ-APKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 395

  Fly   379 GQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENK 443
            |...:.:::.|||..:||: .||.....|:::|.|||:|.||||||.||...|:.||.|:.|.|:
Mouse   396 GSLRVRTVDSYDPVKDQWT-SVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 459

  Fly   444 WSKVAPMTTRRLGVAVAVLGGFLYAIGGSDG---QCPLNTVERYDPRHNKWVAVSPMSTRRKHLG 505
            |..||||.|||..|.|.|:||.|||:||.||   || |:|||.|:...|:|..::.|||||...|
Mouse   460 WFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-LSTVECYNATANEWTYIAEMSTRRSGAG 523

  Fly   506 CAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSA 570
            ..|.||.:|||||.|..:...|.|.|:|.||.|..:..|...|...|:..|||.||.|||.|||.
Mouse   524 VGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSC 588

  Fly   571 YLKTIEVYDPETNQWR-LCGCMNYRRLGGGVGVMRAP 606
            .|.::|.|:|.|::|. :..||:..|...||.|:..|
Mouse   589 NLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKP 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	65/177 (37%)
		PHA03098	69..587	CDD:222983	242/555 (44%)
		KELCH repeat	359..403	CDD:276965	16/43 (37%)
		KELCH repeat	407..451	CDD:276965	24/43 (56%)
		KELCH repeat	454..497	CDD:276965	22/45 (49%)
		KELCH repeat	501..545	CDD:276965	18/43 (42%)
		KELCH repeat	548..593	CDD:276965	21/45 (47%)
Klhl2	XP_017168500.1	BTB_POZ	35..188	CDD:365784	57/152 (38%)
		PHA03098	56..606	CDD:222983	241/552 (44%)
		BACK_KLHL2_Mayven	186..315	CDD:350587	57/128 (45%)
		KELCH repeat	376..419	CDD:276965	16/43 (37%)
		KELCH repeat	423..467	CDD:276965	24/43 (56%)
		KELCH repeat	519..563	CDD:276965	18/43 (42%)
		KELCH repeat	566..612	CDD:276965	21/45 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820