Protein Alignment dbo and Klhl24

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_083712.4
• Gene: Klhl24 / 75785
• MGIID: 1923035
• Length: 600
• Species: Mus musculus
• Alignment Length: 590
• Identity: 219/590 - (37%)
• Similarity: 302/590 - (51%)
• Gaps: 54/590 - (9%)

  Fly    50 TSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVT 114
            :...|.:..|...|..|..|...||::.|.|::...||.:||||||||.|||..:..|||:..|.
Mouse    44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVE 108

  Fly   115 IRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRA 179
            |..|...|||..:.:.||..:.:...|||.|...:.|.|:..::|.|.:||:.||||.|||||:.
Mouse   109 INGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQR 173

  Fly   180 FADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLK 244
            ||||||.:.|......|....|::|.:.||||.|...:|:|.||||||.:..||.||.|||.|:.
Mouse   174 FADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVY 238

  Fly   245 YNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQG 309
            ..|..||..|.::|.|||||||.|.:.|.||..|.|:::...|..|:.||:.|.:|..|   |..
Mouse   239 RAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMS 300

  Fly   310 PRTRPRKPTRRGEVLFAVGGWC---SGDAIASVERFDPQTNDWKMVAPM---SKRRCGVGVAVLN 368
            ||||||:.|...||:..||| |   .|..:...|.:||.|.:||.:|.:   :|....| .|:.|
Mouse   301 PRTRPRRSTGYSEVIVVVGG-CERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAV-CALRN 363

  Fly   369 DLLYAVGGHDGQSYLNS--IERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCL 431
            |:|.: ||.     :||  :..|:.|.|.| ..||.....|....:|||.|.:|.|||.||...|
Mouse   364 DILVS-GGR-----INSRDVWIYNSQLNIW-IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRL 421

  Fly   432 NHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGG--SDGQCPLNTVERYDPRHNKWVAV 494
            :.||.||...|:|::|||:.......||....|.|:.|||  .|..|. :.|:.|||..|.|:..
Mouse   422 SSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCS-DKVQSYDPETNSWLLR 485

  Fly   495 SPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAER-YNPLTNTWSPIVAMTSRRSGVGLAVVNG 558
            :.:...::.:.....||.||..||      |:.|.. |:|:.:.|..:....||:...|::|.||
Mouse   486 AAIPIAKRCITAVSLNNLIYVAGG------LTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNG 544

  Fly   559 QLYAVGG--FDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWC------- 614
            ::|.:||  .:|.| ..||..|||.|:            :..||..|  |:..:|..|
Mouse   545 KIYILGGRRENGEA-TDTILCYDPATS------------IITGVAAM--PRPVSYHGCVTIHRYN 594

  Fly   615 ENSFK 619
            |..||
Mouse   595 EKCFK 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	49/125 (39%)
		PHA03098	69..587	CDD:222983	206/530 (39%)
		KELCH repeat	359..403	CDD:276965	15/45 (33%)
		KELCH repeat	407..451	CDD:276965	21/43 (49%)
		KELCH repeat	454..497	CDD:276965	15/44 (34%)
		KELCH repeat	501..545	CDD:276965	11/44 (25%)
		KELCH repeat	548..593	CDD:276965	15/46 (33%)
Klhl24	NP_083712.4	BTB_POZ_KLHL24_KRIP6	48..168	CDD:349562	47/119 (39%)
		PHA03098	62..566	CDD:222983	202/523 (39%)
		Kelch 1	314..363		16/50 (32%)
		KELCH repeat	354..393	CDD:276965	15/46 (33%)
		Kelch 2	365..407		15/48 (31%)
		KELCH repeat	397..441	CDD:276965	21/43 (49%)
		Kelch 3	408..454		18/45 (40%)
		KELCH repeat	444..489	CDD:276965	15/45 (33%)
		Kelch 4	456..502		12/46 (26%)
		KELCH repeat	492..529	CDD:276965	11/42 (26%)
		Kelch 5	504..544		13/45 (29%)
		KELCH repeat	536..578	CDD:276965	17/54 (31%)
		Kelch	545..591	CDD:128874	17/60 (28%)
		Kelch 6	546..592		17/60 (28%)