DRSC/TRiP Functional Genomics Resources

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Protein Alignment dbo and Klhl40

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_082478.1 Gene:Klhl40 / 72330 MGIID:1919580 Length:621 Species:Mus musculus


Alignment Length:577 Identity:167/577 - (28%)
Similarity:252/577 - (43%) Gaps:78/577 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 HRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYT 132
            |.:..|.|:.||.|:...||::|:|||.||.|.|..|.:.:  .||.:.::..:.:..::.:.||
Mouse    29 HGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSA--GEVRLEEVSPDVVSQVLHYLYT 91

  Fly   133 AHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFT 197
            :.|.::|::||.|..||...|:..|..||..||:::|...|||.:........|..|...|..|.
Mouse    92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFI 156

  Fly   198 QHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYN----VAERRQHLAQVL 258
            ...|..|....:||.|...:|:.||.||.|||..||.||.|||.|....    .|||::.|..|.
Mouse   157 CARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVF 221

  Fly   259 QHVRLPLLSPKFLVGTVGSDLLVRSD-EACR--DLVDEA-KNYLLLPQERPLMQGPRTRPRKPTR 319
            :.||..||...||...|....||||. |..|  .:|.:| :..|...:::...:|.:|...|...
Mouse   222 ESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEAN 286

  Fly   320 RG-----------------------------EVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPM 355
            :|                             :::|.:.   ...|:|    :||..|:. ..|.:
Mouse   287 QGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMIS---EEGAVA----YDPAANEC-YCASL 343

  Fly   356 SKR--RCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQT----------NQW-SCDVAPTTSCR 407
            |.:  :..|.:....:.::..||    .:.|...:.||.:          ::| .....|:..|.
Mouse   344 STQIPKNHVSLVTKENQVFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCL 404

  Fly   408 TSVGVAVLDGFLYAVGG---QDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAI 469
            ..:|.|:  ..:|.|||   :|....|:.|..||....||.:..|:.....|..|......:|.|
Mouse   405 FGLGEAL--NAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVI 467

  Fly   470 G--GSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYN 532
            |  |.|.:| ||.:..|||:..:|..::||.|.|...|..|.:..|:...|..|....||:|.|:
Mouse   468 GGKGKDRKC-LNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYS 531

  Fly   533 PLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTI--EVYDPETNQ-WR 586
            ...|.|:...|....||.:.|..:.|.|||:|||   |.|:|.  |:...|.|. ||
Mouse   532 IADNKWTSFEAFPQERSSLSLVSLAGTLYALGGF---ATLETESGELVPTELNDIWR 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 37/107 (35%)
PHA03098 69..587 CDD:222983 166/576 (29%)
KELCH repeat 359..403 CDD:276965 7/54 (13%)
KELCH repeat 407..451 CDD:276965 14/46 (30%)
KELCH repeat 454..497 CDD:276965 14/44 (32%)
KELCH repeat 501..545 CDD:276965 13/43 (30%)
KELCH repeat 548..593 CDD:276965 18/42 (43%)
Klhl40NP_082478.1 BTB 23..125 CDD:279045 33/97 (34%)
PHA03098 47..594 CDD:222983 161/559 (29%)
BACK 133..239 CDD:285009 38/105 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..298 5/32 (16%)
KELCH repeat 351..398 CDD:276965 7/50 (14%)
Kelch 1. /evidence=ECO:0000255 360..412 10/57 (18%)
KELCH repeat 402..448 CDD:276965 14/47 (30%)
Kelch 2. /evidence=ECO:0000255 413..462 14/48 (29%)
Kelch 414..462 CDD:128874 14/47 (30%)
KELCH repeat 452..497 CDD:276965 15/45 (33%)
Kelch 463..510 CDD:128874 18/47 (38%)
Kelch 3. /evidence=ECO:0000255 463..510 18/47 (38%)
Kelch_1 499..538 CDD:279660 11/38 (29%)
KELCH repeat 500..545 CDD:276965 13/44 (30%)
Kelch 4. /evidence=ECO:0000255 512..557 13/44 (30%)
Kelch_1 547..594 CDD:279660 18/42 (43%)
KELCH repeat 547..594 CDD:276965 18/42 (43%)
Kelch 5. /evidence=ECO:0000255 559..613 14/30 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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