Protein Alignment dbo and Klhl35

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_006508283.1
• Gene: Klhl35 / 72184
• MGIID: 1919434
• Length: 579
• Species: Mus musculus
• Alignment Length: 514
• Identity: 160/514 - (31%)
• Similarity: 245/514 - (47%)
• Gaps: 38/514 - (7%)

  Fly    54 HPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDI 118
            |.:..|..||..||...|.||||..|||....||..|||.|::|..:|.....|.....|.:...
Mouse    22 HAQRILQTLNAYRRSGTLTDVVLRAGGRDFPCHRAALSAASAHFRGLFAAGRPERAAAVVPVGPE 86

  Fly   119 DEN---AMELLIDFCYTAHI-IVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRA 179
            ...   |:.:::|:.|.|.: :..|.....:|..|..|.:..:::.|..||:.:|...|.|.:|.
Mouse    87 TPGTAAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACARFLEGRLRAANSLALRR 151

  Fly   180 FADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLK 244
            .|...|...|.....:..:..|.||....:||.|...::..::....|.|..||.||.|.|.|::
Mouse   152 VAAAFSLASLAERCGRVLRQAFVEVTRHADFLELAPDEVAALLADPALRVAREEAVFEAAMRWVR 216

  Fly   245 YNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQG 309
            ::...||..|.::|:|||||||:|.:.:..|.:|.|:::...||.|:.||:...:|.:|...:
Mouse   217 HDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGDCRPLLLEARACFILGREAGAL-- 279

  Fly   310 PRTRPRKPTRRGEVLFAVGGWCSGDAIASV---ERFDPQTNDWKMV--APMSKRRCGVGVAVLND 369
             |.|||:.....||:..:|| |....:..:   :.:.|::..|..:  .|...|......|:.||
Mouse   280 -RARPRRFMDLAEVIVVIGG-CDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFASCALRND 342

  Fly   370 LLYAVGGHDGQSYLNS--IERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLN 432
             :|..|||     :||  :..:....|.| ..||.....|....:..|.|.|:||||.||::.|.
Mouse   343 -IYVSGGH-----INSRDVWMFSSHLNTW-IKVASMHKGRWRHKMVALQGQLFAVGGFDGLRRLR 400

  Fly   433 HVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNT--VERYDPRHNKWVAVS 495
            .||||||..|.|:.:||:.......|||...|.||.|||: ||..:||  |:.:||:.::|...|
Mouse   401 SVERYDPFSNTWAAIAPLPEAVSSAAVAPCAGQLYVIGGA-GQDGVNTDKVQCFDPKEDQWSLRS 464

  Fly   496 PMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTW-------SPIVAMTSR 547
            |....::.|......:.||.|||.     :|....|:|.::.|       ||:|: ||:
Mouse   465 PAPFLQRCLEAVSLEDTIYVVGGL-----MSKIFTYDPGSDVWREAADLPSPVVS-TSK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	37/125 (30%)
		PHA03098	69..587	CDD:222983	154/499 (31%)
		KELCH repeat	359..403	CDD:276965	13/45 (29%)
		KELCH repeat	407..451	CDD:276965	21/43 (49%)
		KELCH repeat	454..497	CDD:276965	18/44 (41%)
		KELCH repeat	501..545	CDD:276965	13/50 (26%)
		KELCH repeat	548..593	CDD:276965	160/514 (31%)
Klhl35	XP_006508283.1	BTB_POZ_KLHL35	17..148	CDD:349574	37/125 (30%)
		BACK	<171..254	CDD:475122	30/82 (37%)
		NanM	293..511	CDD:442289	70/231 (30%)
		KELCH repeat	331..371	CDD:276965	14/46 (30%)
		KELCH repeat	375..419	CDD:276965	21/43 (49%)
		KELCH repeat	422..467	CDD:276965	19/45 (42%)
		KELCH repeat	470..510	CDD:276965	10/44 (23%)