Protein Alignment dbo and Klhl13

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001368820.1
• Gene: Klhl13 / 67455
• MGIID: 1914705
• Length: 660
• Species: Mus musculus
• Alignment Length: 570
• Identity: 187/570 - (32%)
• Similarity: 299/570 - (52%)
• Gaps: 35/570 - (6%)

  Fly    34 GSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGR--KIFAHRVILSACSSY 96
            |||.:          .||..|..|.|...:.||....||||.|..|..  ....|||::::.|.|
Mouse    69 GSTRI----------FTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDY 123

  Fly    97 FCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDIC 161
            |.|||||.::|.....:.:..:....:..:|||.|||.:.:....:|..|.||..||::.:.|.|
Mouse   124 FKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 188

  Fly   162 CEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDE 226
            ..||...:...||:.:...|:|:...|:.:..:.|...||..::.:.|||.||..:|..::.|:.
Mouse   189 KVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNS 253

  Fly   227 LNVRSEEQVFNAVMSWLKYNVAERRQHL-AQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDL 290
            |...:|..:|.|...||:  :.|.|..: |::::::|.||::|:.|:..|.:...:|:|..|.:|
Mouse   254 LKRCTELDLFKATCRWLR--LEEPRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNL 316

  Fly   291 VDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVE--RFDPQTNDWKMVA 353
            :.||.||.::|..:|:||..||..|..|.|   |..:||......:.|.|  .:|.:|::||.:|
Mouse   317 LLEASNYQMMPFMQPVMQSDRTAIRSDTTR---LVTLGGVLRQQLVVSKELRMYDEKTHEWKSLA 378

  Fly   354 PMSKRRCGVGVAVLNDLLYAVGGHD-----GQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVA 413
            ||...|...|:||:.:.||.|||..     |::.::::.|:||:.|:| ..||.....||...::
Mouse   379 PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW-IQVASLNEKRTFFHLS 442

  Fly   414 VLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPL 478
            .|.||||||||::....|..||.|:|:.|:|:.||.|.....|.|..|.||.:|..||.......
Mouse   443 ALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQ 507

  Fly   479 NTVERYDPRHNKWVAVSPMST-RRKHLGCAVFNNYIYAVGGR-----DDCMELSSAERYNPLTNT 537
            ..:..:||..:||...:||:| |..|..|.| .:.:|.:||.     .|..::.|.|.|:|:.:.
Mouse   508 KELMCFDPDTDKWTQKAPMTTVRGLHCMCTV-GDRLYVIGGNHFRGTSDYDDVLSCEYYSPILDQ 571

  Fly   538 WSPIVAMTSRRSGVGLAVVNGQLYAVGGF--DGSAYLKTIEVYDPETNQW 585
            |:||.:|...:|.||:||...::|.|||:  :....::.::.||||.|:|
Mouse   572 WTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	43/128 (34%)
		PHA03098	69..587	CDD:222983	177/535 (33%)
		KELCH repeat	359..403	CDD:276965	17/48 (35%)
		KELCH repeat	407..451	CDD:276965	20/43 (47%)
		KELCH repeat	454..497	CDD:276965	12/42 (29%)
		KELCH repeat	501..545	CDD:276965	14/48 (29%)
		KELCH repeat	548..593	CDD:276965	15/40 (38%)
Klhl13	NP_001368820.1	BTB_POZ_KLHL9_13	74..201	CDD:349548	41/126 (33%)
		PHA03098	97..640	CDD:222983	176/532 (33%)
		KELCH repeat	384..432	CDD:276965	17/48 (35%)
		KELCH repeat	436..480	CDD:276965	20/43 (47%)
		KELCH repeat	483..528	CDD:276965	14/44 (32%)
		KELCH repeat	530..579	CDD:276965	15/49 (31%)
		KELCH repeat	582..629	CDD:276965	15/40 (38%)