DRSC/TRiP Functional Genomics Resources

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Protein Alignment dbo and KLHL25

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_071925.2 Gene:KLHL25 / 64410 HGNCID:25732 Length:589 Species:Homo sapiens


Alignment Length:591 Identity:194/591 - (32%)
Similarity:286/591 - (48%) Gaps:44/591 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 NSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRV 88
            :.|....||.||..|       .|.|.: .||...|..||.||:|....||.|..|.|....||.
Human     6 HETRKSRSSTGSMNV-------TLFHKA-SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRA 62

  Fly    89 ILSACSSYFCAMFTGELEESRQTEVTIRD-IDENAMELLIDFCYTAHIIVEESNVQTLLPAACLL 152
            :|:|.|.||.|||:..|.|||...|..:| :....:|||:||.|::.|.:.|.|.::||.|..:|
Human    63 VLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDML 127

  Fly   153 QLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQ 217
            |..:::|...|||::.|.|:||||:...:|.|.||.|...:.:....:|:.|.:||:|..|....
Human   128 QFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDT 192

  Fly   218 LVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVR 282
            |:|:|.||||....|..||.|::.|:|:::..|:.||.::|:.|||.||....|...|.|:.|:.
Human   193 LLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLM 257

  Fly   283 SDEACRDLVDEA---KNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGG---WCSGDAIASVER 341
            :||..:.::|||   |..:|  |...::..|..||||   .|..|..:||   .|  |.|..|  
Human   258 ADERTKLIMDEALRCKTRIL--QNDGVVTSPCARPRK---AGHTLLILGGQTFMC--DKIYQV-- 313

  Fly   342 FDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIER----YDPQTNQWSCDVAP 402
             |.:..:....|.:...|.....:.:...:|..||...:   |.:.:    ||....:|| ..||
Human   314 -DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSE---NGVSKDVWVYDTVHEEWS-KAAP 373

  Fly   403 TTSCRTSVGVAVLDGFLYAVGGQDGVQ---------CLNHVERYDPKENKWSKVAPMTTRRLGVA 458
            ....|...|.|.|:..||.|||...:.         .|..||:|||..|||..|||:.......|
Human   374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAA 438

  Fly   459 VAVLGGFLYAIGG-SDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDC 522
            |......|:..|| |..:..::.|:.|||..|:|...:......::...||..:.|:.:|| |..
Human   439 VVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTE 502

  Fly   523 MELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRL 587
            ...:||.|::..||.|:.|..||::|..........:||.|||:.|:...||::.|||.::.|..
Human   503 FTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNC 567

  Fly   588 CGCMNY 593
            ...:.|
Human   568 ITTVPY 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 52/127 (41%)
PHA03098 69..587 CDD:222983 177/538 (33%)
KELCH repeat 359..403 CDD:276965 10/47 (21%)
KELCH repeat 407..451 CDD:276965 21/52 (40%)
KELCH repeat 454..497 CDD:276965 12/43 (28%)
KELCH repeat 501..545 CDD:276965 13/43 (30%)
KELCH repeat 548..593 CDD:276965 13/44 (30%)
KLHL25NP_071925.2 BTB_POZ_KLHL25 24..151 CDD:349563 52/127 (41%)
PHA03098 39..566 CDD:222983 179/541 (33%)
BACK_KLHL25_ENC2 144..242 CDD:350589 38/97 (39%)
Kelch 1 296..340 10/48 (21%)
KELCH repeat 330..374 CDD:276965 10/47 (21%)
Kelch 2 341..388 14/50 (28%)
KELCH repeat 378..431 CDD:276965 21/52 (40%)
Kelch 3 389..444 19/54 (35%)
KELCH repeat 434..480 CDD:276965 12/45 (27%)
Kelch 4 446..492 12/45 (27%)
KELCH repeat 482..524 CDD:276965 13/42 (31%)
Kelch 5 494..538 14/44 (32%)
Kelch 6 539..585 13/35 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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