DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and klhl5

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001164413.1	Gene:	klhl5 / 560697	ZFINID:	ZDB-GENE-080424-7	Length:	769	Species:	Danio rerio

Alignment Length:	603	Identity:	253/603 - (41%)
Similarity:	362/603 - (60%)	Gaps:	44/603 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TGGNSTAGGGSSVGSTAVDRPPSPARLSHTS--------------------EKHPKVTLTELNML 65
            |.....:|.|....:..|:...|..|.|::|                    ..|.:.|...:...
Zfish   163 TRAPDASGPGDEENNNNVESDSSSCRTSNSSVTLSSCASMEPCVSDEHFQAHSHAEHTFRRMEAY 227

  Fly    66 RRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFC 130
            .|.|:||||||..|.|:|.|||::||:.|.||.||||.::.|::|.|:.:..:|.:|:.:|:.:.
Zfish   228 LRTRKLCDVVLLAGDRRIPAHRLVLSSVSDYFAAMFTSDVREAKQEEIKMEGVDPDALWVLVQYA 292

  Fly   131 YTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADK 195
            ||..:.:.|..:::||..:|||||..:...||.:|.:||.|:||||||:|||...|.:|.::|..
Zfish   293 YTGRLELREDTIESLLSGSCLLQLSAVVQACCSYLMKQLHPSNCLGIRSFADAQGCLDLHKVAHN 357

  Fly   196 FTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQH 260
            :|..:|.|||..:||||||..::..::.||::||..||.|..|::||::::|..|:..|:.:|.|
Zfish   358 YTMEHFMEVMRHQEFLLLPSCEVEKLLASDDMNVPEEETVVTALLSWVRHDVTTRQSQLSALLAH 422

  Fly   261 VRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLF 325
            :|||||.|:||.....:.|| |....|:.||.||..|.|||:.|||:|.|||||||.|  ...||
Zfish   423 IRLPLLKPQFLADMEANPLL-RDSVECQRLVMEAMKYHLLPERRPLLQSPRTRPRKAT--VGALF 484

  Fly   326 AVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYD 390
            ||||..:.....|:|::..:.:.|:.||.||.||...|||||:|.||.|||.||...||::|.|:
Zfish   485 AVGGMDATKGATSIEQYCLRRDTWRQVAVMSGRRLQFGVAVLDDRLYVVGGRDGLKTLNTVECYN 549

  Fly   391 PQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRL 455
            |::..||. :.|.::.|..:|||||:|.:|||||.||...|:.|||:||:..:||.||.|.|.|.
Zfish   550 PRSKSWSV-MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLSTVERWDPQARQWSFVASMATPRS 613

  Fly   456 GVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRD 520
            .|.||||...|||:||.||...|.:||.:||..|||.:.:|||.||..:|.|.:|.::||:||.|
Zfish   614 TVGVAVLNSKLYAVGGRDGSSCLKSVECFDPHTNKWSSCAPMSKRRGGVGVATWNGFLYAIGGHD 678

  Fly   521 -----------DCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKT 574
                       ||:     |||:|.|:.|:.:..|:..|..||:.::..:||||||:||..||.|
Zfish   679 APASSLASRLSDCV-----ERYDPKTDMWTAVAPMSLSRDAVGVCLLGDRLYAVGGYDGQVYLNT 738

  Fly   575 IEVYDPETNQWR----LC 588
            :|.|||:||:|.    ||
Zfish   739 VEAYDPQTNEWTQVAPLC 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	50/146 (34%)
		PHA03098	69..587	CDD:222983	240/532 (45%)
		KELCH repeat	359..403	CDD:276965	21/43 (49%)
		KELCH repeat	407..451	CDD:276965	24/43 (56%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	17/54 (31%)
		KELCH repeat	548..593	CDD:276965	23/45 (51%)
klhl5	NP_001164413.1	BTB	224..327	CDD:279045	41/102 (40%)
		PHA03098	225..756	CDD:222983	241/539 (45%)
		BACK	336..435	CDD:285009	45/98 (46%)
		Kelch	483..528	CDD:128874	20/44 (45%)
		KELCH repeat	518..561	CDD:276965	21/43 (49%)
		Kelch	529..575	CDD:128874	21/46 (46%)
		KELCH repeat	565..609	CDD:276965	24/43 (56%)
		Kelch	578..621	CDD:128874	24/42 (57%)
		KELCH repeat	612..655	CDD:276965	21/42 (50%)
		Kelch	623..669	CDD:128874	22/45 (49%)
		KELCH repeat	659..709	CDD:276965	17/54 (31%)
		Kelch	671..722	CDD:128874	17/55 (31%)
		KELCH repeat	712..755	CDD:276965	21/42 (50%)
		Kelch	723..767	CDD:128874	20/34 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820