DRSC/TRiP Functional Genomics Resources

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Protein Alignment dbo and KLHL4

DIOPT Version :10

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_476503.1 Gene:KLHL4 / 56062 HGNCID:6355 Length:720 Species:Homo sapiens


Alignment Length:565 Identity:234/565 - (41%)
Similarity:347/565 - (61%) Gaps:25/565 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 SPARL--SHTSE-------------KHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSA 92
            |.|||  .|:.:             .|.:.||.::....:.::||||:|..|..:|.|||::|||
Human   138 STARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202

  Fly    93 CSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEI 157
            .|.||.||||.::.|::|.||.:..:|.||:..|:.:.||..:.::|..:::||.|||||||.::
Human   203 VSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQV 267

  Fly   158 QDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDII 222
            .|:|..||.:||.|:||||||:|.|...|.|||.:|.|:|..:|.||::::||||||..::..::
Human   268 IDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLL 332

  Fly   223 CSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEAC 287
            |||::||..||.:|:|:|.|:.::|..|:..|..:|.::|||||.|:.|.....|.:.. .|..|
Human   333 CSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT-GDLEC 396

  Fly   288 RDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMV 352
            :.|:.||..|.|||:.|.:||.|||:|||.|  ...|:||||..:.....::|::|.:||.|..:
Human   397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTTIEKYDLRTNSWLHI 459

  Fly   353 APMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDG 417
            ..|:.||...||||:::.||.|||.||...||::|.::|....|:. :.|.::.|..:|||.|:|
Human   460 GTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVATLEG 523

  Fly   418 FLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVE 482
            .:|||||.||...||.|||:||:..:|:.||.|:|.|..|.|..|...||||||.||...|.::|
Human   524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSME 588

  Fly   483 RYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRD-----DCMELSS-AERYNPLTNTWSPI 541
            .:||..|||...:|||.||..:|.|.:|.::|.|||.|     .|..||. .|||:|..::||.:
Human   589 YFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTV 653

  Fly   542 VAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWR 586
            ..::..|..|.:..:..:||.|||:||..||.|:|.||.:.|:|:
Human   654 APLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 53/139 (38%)
PHA03098 69..587 CDD:222983 226/524 (43%)
KELCH repeat 359..403 CDD:276965 17/43 (40%)
KELCH repeat 407..451 CDD:276965 23/43 (53%)
KELCH repeat 454..497 CDD:276965 19/42 (45%)
KELCH repeat 501..545 CDD:276965 18/49 (37%)
KELCH repeat 548..593 CDD:276965 17/39 (44%)
KLHL4NP_476503.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..69
PHA03098 176..698 CDD:222983 225/525 (43%)
Kelch 1 430..476 17/45 (38%)
KELCH repeat 466..509 CDD:276965 17/43 (40%)
Kelch 2 477..523 18/46 (39%)
KELCH repeat 513..557 CDD:276965 23/43 (53%)
Kelch 3 525..570 23/44 (52%)
KELCH repeat 560..603 CDD:276965 19/42 (45%)
Kelch 4 571..617 22/45 (49%)
KELCH repeat 607..658 CDD:276965 18/50 (36%)
Kelch 5 619..670 16/50 (32%)
KELCH repeat 660..699 CDD:276965 17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

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