DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dbo and KLHL4

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_476503.1 Gene:KLHL4 / 56062 HGNCID:6355 Length:720 Species:Homo sapiens


Alignment Length:565 Identity:234/565 - (41%)
Similarity:347/565 - (61%) Gaps:25/565 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 SPARL--SHTSE-------------KHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSA 92
            |.|||  .|:.:             .|.:.||.::....:.::||||:|..|..:|.|||::|||
Human   138 STARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202

  Fly    93 CSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEI 157
            .|.||.||||.::.|::|.||.:..:|.||:..|:.:.||..:.::|..:::||.|||||||.::
Human   203 VSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQV 267

  Fly   158 QDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDII 222
            .|:|..||.:||.|:||||||:|.|...|.|||.:|.|:|..:|.||::::||||||..::..::
Human   268 IDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLL 332

  Fly   223 CSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEAC 287
            |||::||..||.:|:|:|.|:.::|..|:..|..:|.::|||||.|:.|.....|.:.. .|..|
Human   333 CSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT-GDLEC 396

  Fly   288 RDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMV 352
            :.|:.||..|.|||:.|.:||.|||:|||.|  ...|:||||..:.....::|::|.:||.|..:
Human   397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTTIEKYDLRTNSWLHI 459

  Fly   353 APMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDG 417
            ..|:.||...||||:::.||.|||.||...||::|.::|....|:. :.|.::.|..:|||.|:|
Human   460 GTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVATLEG 523

  Fly   418 FLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVE 482
            .:|||||.||...||.|||:||:..:|:.||.|:|.|..|.|..|...||||||.||...|.::|
Human   524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSME 588

  Fly   483 RYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRD-----DCMELSS-AERYNPLTNTWSPI 541
            .:||..|||...:|||.||..:|.|.:|.::|.|||.|     .|..||. .|||:|..::||.:
Human   589 YFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTV 653

  Fly   542 VAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWR 586
            ..::..|..|.:..:..:||.|||:||..||.|:|.||.:.|:|:
Human   654 APLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 53/139 (38%)
PHA03098 69..587 CDD:222983 226/524 (43%)
KELCH repeat 359..403 CDD:276965 17/43 (40%)
KELCH repeat 407..451 CDD:276965 23/43 (53%)
KELCH repeat 454..497 CDD:276965 19/42 (45%)
KELCH repeat 501..545 CDD:276965 18/49 (37%)
KELCH repeat 548..593 CDD:276965 17/39 (44%)
KLHL4NP_476503.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..69
BTB 172..276 CDD:279045 43/103 (42%)
PHA03098 176..698 CDD:222983 225/525 (43%)
BACK 284..373 CDD:285009 38/88 (43%)
Kelch 1 430..476 17/45 (38%)
Kelch 431..476 CDD:128874 17/44 (39%)
Kelch_1 465..510 CDD:279660 19/45 (42%)
KELCH repeat 466..509 CDD:276965 17/43 (40%)
Kelch 2 477..523 18/46 (39%)
KELCH repeat 513..557 CDD:276965 23/43 (53%)
Kelch 3 525..570 23/44 (52%)
Kelch 526..570 CDD:128874 23/43 (53%)
KELCH repeat 560..603 CDD:276965 19/42 (45%)
Kelch 571..617 CDD:128874 22/45 (49%)
Kelch 4 571..617 22/45 (49%)
KELCH repeat 607..658 CDD:276965 18/50 (36%)
Kelch 619..670 CDD:128874 16/50 (32%)
Kelch 5 619..670 16/50 (32%)
Kelch_1 659..702 CDD:279660 17/40 (43%)
KELCH repeat 660..699 CDD:276965 17/39 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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