Protein Alignment dbo and KLHL7

DIOPT Version :9

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_006715816.1
• Gene: KLHL7 / 55975
• HGNCID: 15646
• Length: 599
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 185/548 - (33%)
• Similarity: 280/548 - (51%)
• Gaps: 37/548 - (6%)

  Fly    62 LNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELL 126
            :|.:|:.:.||||:|.|..|||.||||:|:|.|.:|..|||..:.||:..||.::|.:.:.:|.|
Human    34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQL 98

  Fly   127 IDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCL-------------GIR 178
            ::|.|||.|.|..:|||:||.||...|:..::.:|.:|||.|:|.:|||             ||.
Human    99 VEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGEAEKVDQSLPECGIS 163

  Fly   179 AFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWL 243
            ..|:...|.||...||.|...:|.||.:::|||.|.|.::..::..|.|.||:|:||::|.:.||
Human   164 VLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 228

  Fly   244 KYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNY-LLLPQER-PL 306
            ||:...|:..:..:|..||.||:|..||..||.::.|::.:..|..:|.....| ||.|::| .|
Human   229 KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 293

  Fly   307 MQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMV-APMSKRRCGVGVAVLNDL 370
            :.|  ||||:  ::.:...|:.|   |....|...|:|:...|..: .|..||| .......:::
Human   294 VDG--TRPRR--KKHDYRIALFG---GSQPQSCRYFNPKDYSWTDIRCPFEKRR-DAACVFWDNV 350

  Fly   371 LYAVGGHDGQSYLNSIER---YDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQD-GVQCL 431
            :|.:||    |.|..|:|   |:...:.|...:.|.|. |.|:.....:|.:|..||.: |...|
Human   351 VYILGG----SQLFPIKRMDCYNVVKDSWYSKLGPPTP-RDSLAACAAEGKIYTSGGSEVGNSAL 410

  Fly   432 NHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQ----CPLNTVERYDPRHNKWV 492
            ...|.||.:...|.....|.|:|....:....|.:|..|||.|.    ..||:.|.|||....|.
Human   411 YLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWT 475

  Fly   493 AVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVN 557
            .:.||...||:.|.....:.|:||||::....|.:.|.|:...|.|..:..|..:...|..|.|.
Human   476 ELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVG 540

  Fly   558 GQLYAVGGFDGSAYLKTIEVYDPETNQW 585
            ..:|.:.||.|...|..|..|:.||::|
Human   541 SIVYVLAGFQGVGRLGHILEYNTETDKW 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	52/126 (41%)
		PHA03098	69..587	CDD:222983	183/541 (34%)
		KELCH repeat	359..403	CDD:276965	10/46 (22%)
		KELCH repeat	407..451	CDD:276965	12/44 (27%)
		KELCH repeat	454..497	CDD:276965	14/46 (30%)
		KELCH repeat	501..545	CDD:276965	13/43 (30%)
		KELCH repeat	548..593	CDD:276965	13/38 (34%)
KLHL7	XP_006715816.1	BTB_POZ_KLHL7	23..148	CDD:349546	51/113 (45%)
		PHA03098	37..568	CDD:222983	183/543 (34%)
		BACK	140..250	CDD:391941	38/109 (35%)
		KELCH repeat	385..429	CDD:276965	12/43 (28%)
		KELCH repeat	433..481	CDD:276965	15/47 (32%)
		KELCH repeat	484..528	CDD:276965	13/43 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820