DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and klhl40a

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001122154.1	Gene:	klhl40a / 553257	ZFINID:	ZDB-GENE-050916-1	Length:	612	Species:	Danio rerio

Alignment Length:	620	Identity:	166/620 - (26%)
Similarity:	277/620 - (44%)	Gaps:	69/620 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYF 97
            :.|.:||....|.....|..:.....|.:.|      :..|.:|.:..::...||::|:|.|.||
Zfish     1 MASMSVDPVTEPRMYQQTLLQDGLCDLLDAN------KFVDCILKIKDKEFPCHRLVLAATSPYF 59

  Fly    98 CAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICC 162
            .|||..:||||::.|:.::||:...|.:::.:.||:.|.:.|.|||.:..||.:.|:..|..:|.
Zfish    60 KAMFLSDLEESKKREIVLKDIEPGIMGMILRYIYTSDINLTEQNVQDIFMAANMYQIPSIFSVCV 124

  Fly   163 EFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDEL 227
            .:|:::|..:|||.|........|..|...|..|....:..::..::|..|...:|..||..|.|
Zfish   125 SYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFICDRYLLIIRDQDFHQLGPSELAAIITCDSL 189

  Fly   228 NVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACR---D 289
            ||..||.||.::|.|::|:..||.:.|.::|..||..|:...:....|....|:|:::..:   .
Zfish   190 NVEREESVFESLMDWVEYDTDERTKELPELLHCVRFRLMPTSYFKEKVEGHRLIRTNQELKKELQ 254

  Fly   290 LVDEAKNYLLLPQERP--------------------LMQG-PRTRPRKPTRRGEVLFAVGGWCSG 333
            |:.:|:..||...:|.                    |:.| ....||....:.:::..:..
Zfish   255 LIKDAQKGLLHRVKRSSHRKEGKSAEFESDDDDEDGLLPGILNDNPRFGMFQSDLILMIND---- 315

  Fly   334 DAIASVERFDPQTNDWKMVAPMS----KRRCGVGVAVLNDLLYAVGG------HDGQSYLNSIER 388
               |....:|...|:. .||..|    |..|  .:....:.::.|||      :..|.:.:...:
Zfish   316 ---AGTVAYDVGANEC-FVASSSTEIPKNHC--SLVTKENQIFVVGGLRYNEENKDQPFSSYFLQ 374

  Fly   389 YDPQTNQW-SCDVAPTTSCRTSVGVAVLDGFLYAVGG---QDGVQCLNHVERYDPKENKWSKVAP 449
            :||.:::| .....|...|  ..|:...:..:|.|||   ::|.:.|:.|..||.:..||.:..|
Zfish   375 FDPMSSEWLGMPSLPNPRC--LFGLVEAENSIYVVGGKELKEGERALDSVMIYDRQSFKWGESDP 437

  Fly   450 MTTRRLGVAVAVLGGFLYAIGG-SDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYI 513
            :.....|..:....|.:|.||| ::.:..|..|..|||...:|..::||.|.|...|.||..|.|
Zfish   438 LPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKFEWKDLAPMKTARSLFGTAVHKNKI 502

  Fly   514 YAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGF-----DGSAYLK 573
            |.|.|..|....|:.|.|:..:|:||..|.....||.:.|..:.|.|||:|||     :.:..|:
Zfish   503 YVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLVELGGFLYAIGGFAMMPNETTEKLE 567

  Fly   574 TIEV-----YDPETNQWRLCGCMNYRRLGGGVGVM 603
            ..|:     :|.|.|.|.  |.:...|...|..|:
Zfish   568 PTEMNDIWKFDEEENCWN--GILREIRYAAGATVL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	39/126 (31%)
		PHA03098	69..587	CDD:222983	155/566 (27%)
		KELCH repeat	359..403	CDD:276965	8/50 (16%)
		KELCH repeat	407..451	CDD:276965	13/46 (28%)
		KELCH repeat	454..497	CDD:276965	12/43 (28%)
		KELCH repeat	501..545	CDD:276965	17/43 (40%)
		KELCH repeat	548..593	CDD:276965	17/54 (31%)
klhl40a	NP_001122154.1	BTB	26..128	CDD:279045	34/107 (32%)
		PHA03098	48..540	CDD:222983	139/503 (28%)
		BACK	136..236	CDD:197943	30/99 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		1/23 (4%)
		KELCH repeat	341..388	CDD:276965	8/48 (17%)
		Kelch 1	350..402		10/53 (19%)
		Kelch	350..398	CDD:128874	10/49 (20%)
		Kelch_1	391..432	CDD:279660	11/42 (26%)
		KELCH repeat	392..438	CDD:276965	13/47 (28%)
		Kelch 2	403..452		13/48 (27%)
		KELCH repeat	442..487	CDD:276965	13/44 (30%)
		Kelch	453..500	CDD:128874	17/46 (37%)
		Kelch 3	453..500		17/46 (37%)
		Kelch_1	489..529	CDD:279660	15/39 (38%)
		KELCH repeat	490..535	CDD:276965	17/44 (39%)
		Kelch 4	502..547		15/44 (34%)
		Kelch 5	549..604		16/54 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810