Protein Alignment dbo and klhl40a

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001122154.1
• Gene: klhl40a / 553257
• ZFINID: ZDB-GENE-050916-1
• Length: 612
• Species: Danio rerio
• Alignment Length: 620
• Identity: 166/620 - (26%)
• Similarity: 277/620 - (44%)
• Gaps: 69/620 - (11%)

  Fly    33 VGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYF 97
            :.|.:||....|.....|..:.....|.:.|      :..|.:|.:..::...||::|:|.|.||
Zfish     1 MASMSVDPVTEPRMYQQTLLQDGLCDLLDAN------KFVDCILKIKDKEFPCHRLVLAATSPYF 59

  Fly    98 CAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICC 162
            .|||..:||||::.|:.::||:...|.:::.:.||:.|.:.|.|||.:..||.:.|:..|..:|.
Zfish    60 KAMFLSDLEESKKREIVLKDIEPGIMGMILRYIYTSDINLTEQNVQDIFMAANMYQIPSIFSVCV 124

  Fly   163 EFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDEL 227
            .:|:::|..:|||.|........|..|...|..|....:..::..::|..|...:|..||..|.|
Zfish   125 SYLQQKLVLSNCLAIFRLGLLLDCPRLAMEARDFICDRYLLIIRDQDFHQLGPSELAAIITCDSL 189

  Fly   228 NVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACR---D 289
            ||..||.||.::|.|::|:..||.:.|.::|..||..|:...:....|....|:|:::..:   .
Zfish   190 NVEREESVFESLMDWVEYDTDERTKELPELLHCVRFRLMPTSYFKEKVEGHRLIRTNQELKKELQ 254

  Fly   290 LVDEAKNYLLLPQERP--------------------LMQG-PRTRPRKPTRRGEVLFAVGGWCSG 333
            |:.:|:..||...:|.                    |:.| ....||....:.:::..:..
Zfish   255 LIKDAQKGLLHRVKRSSHRKEGKSAEFESDDDDEDGLLPGILNDNPRFGMFQSDLILMIND---- 315

  Fly   334 DAIASVERFDPQTNDWKMVAPMS----KRRCGVGVAVLNDLLYAVGG------HDGQSYLNSIER 388
               |....:|...|:. .||..|    |..|  .:....:.::.|||      :..|.:.:...:
Zfish   316 ---AGTVAYDVGANEC-FVASSSTEIPKNHC--SLVTKENQIFVVGGLRYNEENKDQPFSSYFLQ 374

  Fly   389 YDPQTNQW-SCDVAPTTSCRTSVGVAVLDGFLYAVGG---QDGVQCLNHVERYDPKENKWSKVAP 449
            :||.:::| .....|...|  ..|:...:..:|.|||   ::|.:.|:.|..||.:..||.:..|
Zfish   375 FDPMSSEWLGMPSLPNPRC--LFGLVEAENSIYVVGGKELKEGERALDSVMIYDRQSFKWGESDP 437

  Fly   450 MTTRRLGVAVAVLGGFLYAIGG-SDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYI 513
            :.....|..:....|.:|.||| ::.:..|..|..|||...:|..::||.|.|...|.||..|.|
Zfish   438 LPYAVYGHGIVSHKGLVYVIGGKTESKKCLRRVCVYDPSKFEWKDLAPMKTARSLFGTAVHKNKI 502

  Fly   514 YAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGF-----DGSAYLK 573
            |.|.|..|....|:.|.|:..:|:||..|.....||.:.|..:.|.|||:|||     :.:..|:
Zfish   503 YVVTGVTDNGLTSTVEVYDIASNSWSEFVDFPQERSSLNLVELGGFLYAIGGFAMMPNETTEKLE 567

  Fly   574 TIEV-----YDPETNQWRLCGCMNYRRLGGGVGVM 603
            ..|:     :|.|.|.|.  |.:...|...|..|:
Zfish   568 PTEMNDIWKFDEEENCWN--GILREIRYAAGATVL 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	39/126 (31%)
		PHA03098	69..587	CDD:222983	155/566 (27%)
		KELCH repeat	359..403	CDD:276965	8/50 (16%)
		KELCH repeat	407..451	CDD:276965	13/46 (28%)
		KELCH repeat	454..497	CDD:276965	12/43 (28%)
		KELCH repeat	501..545	CDD:276965	17/43 (40%)
		KELCH repeat	548..593	CDD:276965	17/54 (31%)
klhl40a	NP_001122154.1	BTB_POZ_KLHL40_KBTBD5	7..140	CDD:349649	42/138 (30%)
		PHA03098	48..540	CDD:222983	139/503 (28%)
		BACK_KLHL40_KBTBD5	131..229	CDD:350591	32/97 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290		1/23 (4%)
		KELCH repeat	341..388	CDD:276965	8/48 (17%)
		Kelch 1	350..402		10/53 (19%)
		KELCH repeat	392..438	CDD:276965	13/47 (28%)
		Kelch 2	403..452		13/48 (27%)
		KELCH repeat	442..487	CDD:276965	13/44 (30%)
		Kelch 3	453..500		17/46 (37%)
		KELCH repeat	490..535	CDD:276965	17/44 (39%)
		PRK14131	500..>585	CDD:237617	28/84 (33%)
		Kelch 4	502..547		15/44 (34%)
		Kelch 5	549..604		16/54 (30%)