DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dbo and Keap1

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_001103775.1 Gene:Keap1 / 50868 MGIID:1858732 Length:624 Species:Mus musculus


Alignment Length:630 Identity:229/630 - (36%)
Similarity:343/630 - (54%) Gaps:39/630 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PRDAAVTGTGGNSTAGGGSSV--GSTAVDRPPSPAR-----LSHTSEKHPKVTLTELNMLRRHRE 70
            ||.:...........|.|.:|  .||......:|::     .|:|.|.|.|.....:|.||..::
Mouse    11 PRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGVMNELRLSQQ 75

  Fly    71 LCDVVL-----NVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFC 130
            ||||.|     ::...:..||:|:|::.|..|.||||..|.|.....|:|..|....||.||:|.
Mouse    76 LCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFA 140

  Fly   131 YTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADK 195
            |||.|.|.|..|..::..|.:.|:..:...|.:||.:||||:|.:||..||:...|.||.:.|.:
Mouse   141 YTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRARE 205

  Fly   196 FTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQH 260
            :...:|.||.:.|||..|...||..:|..|:||||.|.:||:|.:.|:||:..:||.::..:|:.
Mouse   206 YIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRA 270

  Fly   261 VRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLL-LPQERPLMQGPRTRPRKPTRRGEVL 324
            ||...|:|:||...:....::::|..|:|       ||: :.||..|.:..:..|.:..:.|.::
Mouse   271 VRCHALTPRFLQTQLQKCEILQADARCKD-------YLVQIFQELTLHKPTQAVPCRAPKVGRLI 328

  Fly   325 FAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGH----DGQSYLNS 385
            :..||:.. .:::.:|.::|....|..:|.:...|.|:...|:..|||||||.    ||.:..::
Mouse   329 YTAGGYFR-QSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSA 392

  Fly   386 IERYDPQTNQWS-CDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNH--VERYDPKENKWSKV 447
            ::.|:|.||||| |  |..:..|..:||.|:||.:|||||..|  |::|  ||||:|:.::|..|
Mouse   393 LDCYNPMTNQWSPC--ASMSVPRNRIGVGVIDGHIYAVGGSHG--CIHHSSVERYEPERDEWHLV 453

  Fly   448 APMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNY 512
            |||.|||:||.||||...|||:||.||...||:.|.|.|..|:|..::||:|.|...|..|.:|.
Mouse   454 APMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNC 518

  Fly   513 IYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEV 577
            |||.||.|...:|:|.|||:..|.||:.:..|...||.:|:.|..|::|.:||:||..:|.::|.
Mouse   519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVEC 583

  Fly   578 YDPETNQWRLCGCMNYRRLGGGVGVMRAPQTENYMWCENSFKQPN 622
            |||:::.|.....|...|.|.||.|...|       |.....|.|
Mouse   584 YDPDSDTWSEVTRMTSGRSGVGVAVTMEP-------CRKQIDQQN 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 49/131 (37%)
PHA03098 69..587 CDD:222983 203/530 (38%)
KELCH repeat 359..403 CDD:276965 21/48 (44%)
KELCH repeat 407..451 CDD:276965 23/45 (51%)
KELCH repeat 454..497 CDD:276965 21/42 (50%)
KELCH repeat 501..545 CDD:276965 18/43 (42%)
KELCH repeat 548..593 CDD:276965 17/44 (39%)
Keap1NP_001103775.1 BTB 67..176 CDD:279045 39/108 (36%)
PHA03098 95..596 CDD:222983 198/512 (39%)
BACK 184..286 CDD:285009 39/101 (39%)
Kelch 327..372 CDD:128874 9/45 (20%)
Kelch 1 327..372 9/45 (20%)
KELCH repeat 362..409 CDD:276965 21/48 (44%)
Kelch 373..423 CDD:128874 22/51 (43%)
Kelch 2 373..423 22/51 (43%)
KELCH repeat 413..456 CDD:276965 22/44 (50%)
Kelch 3 424..470 27/47 (57%)
Kelch 424..469 CDD:128874 26/46 (57%)
KELCH repeat 460..503 CDD:276965 21/42 (50%)
Kelch 471..517 CDD:128874 20/45 (44%)
Kelch 4 471..517 20/45 (44%)
KELCH repeat 507..551 CDD:276965 18/43 (42%)
Kelch 518..564 CDD:128874 19/45 (42%)
Kelch 5 519..564 19/44 (43%)
KELCH repeat 554..597 CDD:276965 16/42 (38%)
Kelch 565..611 CDD:128874 17/45 (38%)
Kelch 6 565..611 17/45 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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