Protein Alignment dbo and klhl15

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_005162671.1
• Gene: klhl15 / 445186
• ZFINID: ZDB-GENE-040801-99
• Length: 613
• Species: Danio rerio
• Alignment Length: 591
• Identity: 161/591 - (27%)
• Similarity: 262/591 - (44%)
• Gaps: 80/591 - (13%)

  Fly    49 HTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEV 113
            :.|:.|.....:....|...|.|.||.|.:......||:.:|:..|.||..|||.::.|..|.::
Zfish    17 YLSQVHDGSVSSGFKALYEERLLLDVTLLIEEHHFQAHKALLATQSDYFRVMFTADMRERDQDKI 81

  Fly   114 TIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIR 178
            .::.:.......::.|.|...:.:....||.:|.||..:||.|..:.||.||..::    ||
Zfish    82 HMKGLTAAGFGHVLRFMYYGSLELSMLTVQEILQAAMYVQLTEAVEFCCSFLLAKI----CL--- 139

  Fly   179 AFADTHSCRELLRI--------------ADKFTQHNFQEVMESEEFL-LLPVGQLVDIICSDELN 228
                 .:|.|::|:              .|.|...||..:|...:|| .|.:.:|:..:.||:|:
Zfish   140 -----ENCAEVMRLLEDFSVGVEGVQEQLDAFLLENFVPLMARPDFLSYLSLEKLMAYLDSDQLS 199

  Fly   229 VRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDE 293
            ...|.:::.||.:||::: ..|.:|...|:|::|..|::|..:...|.:....|.....|..||:
Zfish   200 RFPEIELYEAVQAWLRHD-RRRWRHTDAVVQNLRFCLMTPANIFEKVKTSEFYRYSRQLRLEVDQ 263

  Fly   294 AKNYLLLPQERPLMQGP-----RTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVA 353
            |.:|.....|:||.:..     ..||:....||    .:|.......|..:.|  |:. .|::..
Zfish   264 ALSYFHQVNEQPLAETKSNRIRSVRPQTAVFRG----MIGHSMVNSKILLLHR--PKV-WWELEG 321

  Fly   354 PMSKRR--CGVGVAVLNDLLYAVGGH----DGQSYLNS-IERYDPQTNQWSCDVAPTTSCRTSVG 411
            |....|  |   :|::|:..:.:||.    ||:.:.:| :.||||:.|.| ..:|..:..|:...
Zfish   322 PQVPLRPDC---LAIVNNFAFLLGGEELGPDGEFHASSKVYRYDPRQNSW-LRMADMSVPRSEFA 382

  Fly   412 VAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQC 476
            |.|:..::|||.|:...:.....||||..|:||..|.|....:.|....||.|.||..||.....
Zfish   383 VGVIGKYIYAVAGRTRDETFYSTERYDIVEDKWEFVDPYPVNKYGHEGTVLNGKLYITGGITSSS 447

  Fly   477 PLNTVERYDP------RH---------NKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMEL- 525
            ....|..:||      .|         |.|...|.|:..|........|..:|..||  .|:.|
Zfish   448 TSKQVCVFDPGREGSSEHRTRRTPILTNCWENKSKMNYARCFHKMISHNGKLYVFGG--VCVILR 510

  Fly   526 --------SSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGG--FDGSAYLKTIEVYDP 580
                    .|.|.|:|.|:.|:.:.:|...|||.|:||::.|:..:||  ::|. |..:|..:||
Zfish   511 ASFESQGCPSTEVYDPETDEWTILASMPIGRSGHGVAVLDKQIMVLGGLCYNGH-YSDSILTFDP 574

  Fly   581 ETNQWR 586
            |.|:|:
Zfish   575 EENKWK 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	34/126 (27%)
		PHA03098	69..587	CDD:222983	158/571 (28%)
		KELCH repeat	359..403	CDD:276965	16/50 (32%)
		KELCH repeat	407..451	CDD:276965	16/43 (37%)
		KELCH repeat	454..497	CDD:276965	15/57 (26%)
		KELCH repeat	501..545	CDD:276965	13/52 (25%)
		KELCH repeat	548..593	CDD:276965	17/41 (41%)
klhl15	XP_005162671.1	BTB_POZ_KLHL15	10..146	CDD:349553	37/140 (26%)
		PHA03098	52..599	CDD:222983	153/556 (28%)
		BACK_KLHL15	137..244	CDD:350529	29/119 (24%)
		KELCH repeat	330..374	CDD:276965	15/47 (32%)
		KELCH repeat	378..421	CDD:276965	15/42 (36%)
		KELCH repeat	426..483	CDD:276965	15/56 (27%)
		KELCH repeat	487..538	CDD:276965	13/52 (25%)
		KELCH repeat	541..581	CDD:276965	17/41 (41%)