Protein Alignment dbo and IPP

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_005888.1
• Gene: IPP / 3652
• HGNCID: 6108
• Length: 584
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 216/585 - (36%)
• Similarity: 321/585 - (54%)
• Gaps: 30/585 - (5%)

  Fly    42 PSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELE 106
            |..|....:|:||.::.|.::|.:|..:..|||.|.||.....|||::|:|.|.||.|:|||.::
Human     7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMK 71

  Fly   107 ESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDP 171
            ||.:..|.|..|:....::|:||.||..:.:..:|||.|:.||.:|||.|:..:||||||.|:||
Human    72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDP 136

  Fly   172 TNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVF 236
            .||:||..|::..:|.:||..::.:...:|.||...||||.|...||:.|:.|:||::..|.|||
Human   137 LNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVF 201

  Fly   237 NAVMSWLKYNVAERRQHLAQVLQHVRLPLLSP----KFLVGTVGSDLLVRSDEACRDLVDEAKNY 297
            .|.|.|:..::.:||:|:.:||..:|.|||.|    |::.|....:|.|......::..:..|:
Human   202 LAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKS- 265

  Fly   298 LLLPQER---PLMQGPRTRPRKPTRRGEVLFAVGG--------WCSGDAIASVERFDPQTNDWKM 351
               |:|.   ..:|..:.||||..|:  .|:||||        |....|::.|||||..:..|..
Human   266 ---PKENKFCSFLQTSKVRPRKKARK--YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325

  Fly   352 VAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLD 416
            |:.:.:.|.|:||.||..::||:||.......:..|.|||.|.||: .||.....|..:||.|..
Human   326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWT-TVASMNHPRCGLGVCVCY 389

  Fly   417 GFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGG-SDGQCPLNT 480
            |.:||:||..|.:..|.:||:||.||||..|..|...|.......:.|.:|.||| |:....|.:
Human   390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRS 454

  Fly   481 VERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCME-LSSAERYNPLTNTWSPIVAM 544
            .|.|||...:|..:.||.|||.:||.|..|:.||:|||.::..: |.:.|:|:.....|..:.:|
Human   455 FEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519

  Fly   545 TSRRSGVGLAVVNGQLYAVGG------FDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVM 603
            ...|:|:.:..|||.||..||      |.....|.::|||:|.::.|...|.|...|..|||.|:
Human   520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584

  Fly   604  603
            Human   585  584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	55/126 (44%)
		PHA03098	69..587	CDD:222983	201/540 (37%)
		KELCH repeat	359..403	CDD:276965	19/43 (44%)
		KELCH repeat	407..451	CDD:276965	20/43 (47%)
		KELCH repeat	454..497	CDD:276965	13/43 (30%)
		KELCH repeat	501..545	CDD:276965	14/44 (32%)
		KELCH repeat	548..593	CDD:276965	18/50 (36%)
IPP	NP_005888.1	BTB_POZ_KLHL27_IPP	17..141	CDD:349565	54/123 (44%)
		PHA03098	30..575	CDD:222983	204/551 (37%)
		Kelch 1	289..343		20/53 (38%)
		KELCH repeat	333..376	CDD:276965	19/43 (44%)
		Kelch 2	344..390		17/46 (37%)
		KELCH repeat	380..424	CDD:276965	20/43 (47%)
		Kelch 3	391..437		17/45 (38%)
		KELCH repeat	427..473	CDD:276965	15/45 (33%)
		Kelch 4	439..485		19/45 (42%)
		KELCH repeat	475..520	CDD:276965	14/44 (32%)
		Kelch 5	487..533		13/45 (29%)
		KELCH repeat	523..574	CDD:276965	18/50 (36%)
		Kelch 6	535..583		17/47 (36%)