DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and kel-8

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001300209.1	Gene:	kel-8 / 3565011	WormBaseID:	WBGene00020952	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	613	Identity:	207/613 - (33%)
Similarity:	320/613 - (52%)	Gaps:	52/613 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ARLSHT--------------------SEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVI 89
            ||:|:|                    .|:..|: :.::.:||:..|||||.|.|.|..|.|||.|
Worm   102 ARVSYTPFEEFELVSNSKGSCMEYENQEQSSKI-MEQMRILRQTEELCDVELLVAGSVIRAHRYI 165

  Fly    90 LSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQL 154
            |:|.|.||.||||..:.|.::..:.::||.|.::.:::|:.||..|.:..:||..|:..|.:||:
Worm   166 LAAASPYFKAMFTNGMVEMKKLTIELQDIPEESVRIIVDYIYTDKIAITMNNVHQLIFTATVLQM 230

  Fly   155 VEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLV 219
            ..|...|.:||...:...||:.:..|:|.::|..|:...:.|....|:.:.:|.||..:....|.
Worm   231 DVIVVACQQFLATMITSHNCMSLYHFSDIYNCTNLISSIEDFASSQFRCIRKSPEFNSISFHHLK 295

  Fly   220 DIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSD 284
            .::...:|||..|:.||..::.|:..|..:|:.|..|:.:.:||.|:...||...|.|:..|::.
Worm   296 SLLNRSDLNVSEEQDVFETIVQWVSSNPRDRQHHFVQLFKTLRLHLVGWNFLCEAVNSNSYVKNS 360

  Fly   285 EACRDLVDEAKNYLLLPQER-------------------PLMQGPRTRPRKPTRR---GEVLFAV 327
            :.||:::.......:.|.:|                   |.:....:......|:   |.:..|.
Worm   361 QECREIISAMVLDAMTPSKRKHPESNHENTSEYSASMACPSLTASSSSSTSTFRKSVAGAIFCAG 425

  Fly   328 GGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQ 392
            |...:|...:|||.:|.:.|.|..|..|..:|..|||...|..|||:|||||.::|.:.|.:.|.
Worm   426 GRGKAGGPFSSVEAYDWRRNQWIEVPDMMSQRRHVGVVSANGNLYAIGGHDGTAHLATAEAFQPS 490

  Fly   393 TNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGV 457
            ..||. .:|...:.|..:.||.::..:|||||.|...|...|||||.:|::||.||.|..:|.||
Worm   491 IRQWK-RIASMKTARRGIAVASIENVIYAVGGLDDTTCYKTVERYDIEEDEWSTVADMDVQRGGV 554

  Fly   458 AVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDC 522
            .|||:|.:|:||||:||...|.|.||:||..:||..::.|..||...|..|.:.|:||:||.||.
Worm   555 GVAVIGRYLFAIGGNDGTSSLETCERFDPMIDKWKRIASMKNRRAGSGVCVLDGYLYAIGGFDDN 619

  Fly   523 MELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRL 587
            ..|.:.|||:|..:.|..:..|:|.|.|||:|.:.|::||:||.|||.||.|:|.|||..|:|:.
Worm   620 APLETCERYDPDADKWITLDKMSSPRGGVGVAALGGKVYAIGGHDGSDYLNTVECYDPIANRWQP 684

  Fly   588 CGCMNYRRLGGGVG--------VMRAPQ 607
            ...:...|.|.||.        :.|.|:
Worm   685 AAEIKECRAGAGVAWANVRMHQLSRTPE 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	47/146 (32%)
		PHA03098	69..587	CDD:222983	193/539 (36%)
		KELCH repeat	359..403	CDD:276965	19/43 (44%)
		KELCH repeat	407..451	CDD:276965	20/43 (47%)
		KELCH repeat	454..497	CDD:276965	22/42 (52%)
		KELCH repeat	501..545	CDD:276965	16/43 (37%)
		KELCH repeat	548..593	CDD:276965	22/44 (50%)
kel-8	NP_001300209.1	PHA03098	148..635	CDD:222983	166/487 (34%)
		KELCH repeat	457..500	CDD:276965	19/43 (44%)
		KELCH repeat	504..547	CDD:276965	20/42 (48%)
		KELCH repeat	551..595	CDD:276965	22/43 (51%)
		KELCH repeat	598..643	CDD:276965	17/44 (39%)
		KELCH repeat	645..687	CDD:276965	22/41 (54%)
		Kelch	656..698	CDD:128874	19/41 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820