DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and klhl10

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster

Alignment Length:	630	Identity:	201/630 - (31%)
Similarity:	300/630 - (47%)	Gaps:	62/630 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLPGSGSTAQP---RDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVT---LTE 61
            |||  .:.|.|   .|:......|||.......:|...:..       :||....|.|:   |..
  Fly    16 DLP--FALALPPVSMDSLQLNADGNSPEDKTLGIGRKTILN-------AHTKSLAPIVSDEALNT 71

  Fly    62 LNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTG---------ELEESRQTE--VTI 115
            ||.||....|||..::||......||.|:.:|||||.|.|||         :..::::..  :.|
  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHI 136

  Fly   116 RDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAF 180
            ..:....|..:|.:.|.....:.||||..||..|..:.:|.:...|.::|.|.|.|.||:.|..|
  Fly   137 PGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGF 201

  Fly   181 ADTHSCRELLRIADKFTQHNFQEV---------MESEEFLLLPVGQLVDIICSDELNVRSEEQVF 236
            |......:|...|..:|...|.||         |.:|:|        ..||..||||.|.|:.|:
  Fly   202 ARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDF--------YSIISDDELNTREEDHVW 258

  Fly   237 NAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYL--- 298
            ...:.|:..|...|::|:|.::..|||.|::||..:..|.....|...||.:.|:.:...::
  Fly   259 KLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDL 323

  Fly   299 --LLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMV------APM 355
              |.||...|...|...||.|   .||:||:|||..|.:...:|.:|.:.:.|..:      .|
  Fly   324 DFLNPQADELTTPPLAMPRLP---HEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGP- 384

  Fly   356 SKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLY 420
               |...|.|||...::::||:||..|.|:...:|....:|: ::||....|..|.|..|:|.:|
  Fly   385 ---RAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWN-EIAPMHCRRCYVSVTELNGMIY 445

  Fly   421 AVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYD 485
            |:||.||...||.||||:|:.|:||.:.||..:|...:...|...:||.||.:||..|::.|.||
  Fly   446 AIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYD 510

  Fly   486 PRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSG 550
            |..|.|..:..|:.||..:.|..|.|.:|.:||.:....||:.||::|.|.||..|..|...||.
  Fly   511 PVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSN 575

  Fly   551 VGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRR 595
            .||.:::..::|:|||:|.:.:...|.|..||::|.....||..|
  Fly   576 FGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVR 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	45/140 (32%)
		PHA03098	69..587	CDD:222983	179/548 (33%)
		KELCH repeat	359..403	CDD:276965	14/43 (33%)
		KELCH repeat	407..451	CDD:276965	22/43 (51%)
		KELCH repeat	454..497	CDD:276965	15/42 (36%)
		KELCH repeat	501..545	CDD:276965	16/43 (37%)
		KELCH repeat	548..593	CDD:276965	15/44 (34%)
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	34/113 (30%)
		PHA03098	86..610	CDD:222983	175/539 (32%)
		BACK	195..298	CDD:285009	33/110 (30%)
		Kelch	347..394	CDD:128874	15/50 (30%)
		KELCH repeat	385..428	CDD:276965	14/43 (33%)
		Kelch	396..442	CDD:128874	14/46 (30%)
		Kelch_1	431..476	CDD:279660	22/44 (50%)
		KELCH repeat	432..475	CDD:276965	21/42 (50%)
		KELCH repeat	479..523	CDD:276965	15/43 (35%)
		Kelch	490..536	CDD:128874	18/45 (40%)
		Kelch_1	525..570	CDD:279660	17/44 (39%)
		KELCH repeat	526..571	CDD:276965	17/44 (39%)
		Kelch_1	573..617	CDD:279660	14/43 (33%)
		KELCH repeat	573..617	CDD:276965	14/43 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464349
Domainoid	1	1.000	42	1.000	Domainoid score	I4772
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	8	7.890