DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and CG1812

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	165/619 - (26%)
Similarity:	275/619 - (44%)	Gaps:	82/619 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGR 81
            |.|.....:.|...:|..:.....|.||         ..:..|..||.||...:|.||.|.|...
  Fly     2 AATPAPAVTPAATATSAAAKIPVNPVSP---------EEETLLRGLNKLRNEEKLTDVTLIVEEH 57

  Fly    82 KIFAHRVILSACSSYFCAMFTG-ELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTL 145
            :..||||:|:|.|.||||||.. .:.|||:.|:.:..|...||..:||:.||:.:.:...|::.:
  Fly    58 RFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEI 122

  Fly   146 LPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEF 210
            |.||..:|:.|:.|.|..||..:::..|||.|...||.:...:|...|.::...:|:|...:.:|
  Fly   123 LAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDF 187

  Fly   211 LLLPVGQ-----------------LVDIICSDELNVRSEEQVFNAVMSWLKY------NVAERRQ 252
            ..:.|.|                 ||.::||..:..:..|.....::..:|:      :|.|.|.
  Fly   188 KEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRN 252

  Fly   253 HLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKP 317
            ....:.:..:|||.:..:             :...::.:....|.::..:::.|.|||      .
  Fly   253 MNCSLDKGKQLPLPTSYY-------------NRIKQEHMGHLLNGVVSLKDQSLPQGP------T 298

  Fly   318 TRRGE--VLFAVGGWCSGDAIASVERFDPQTNDW-KMVAPMSKRRCGVGVAVLNDLLYAVGG-HD 378
            ..||.  .|..:||:........:..|.|:..:| ::.|.....:|..|.||||:.|:.||| :|
  Fly   299 NMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYD 363

  Fly   379 G--QSYLNSIE-RYDPQTNQWSCDVAPTTS--CRTSVGVAVLDGFLYAVGG------QDGVQCLN 432
            .  :.|::... .|.|..|.| ..:||...  ||.|:. ||....||||||      ::.::.::
  Fly   364 VFLKEYIHPFGFCYCPLRNTW-MTIAPIQQDRCRFSLN-AVGTQHLYAVGGILDDDNEEALRMIS 426

  Fly   433 HVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPM 497
            :|||||..:|.|:.:..:...|...|..|:|..||..||......|.::..:|.:...|..::.|
  Fly   427 NVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASM 491

  Fly   498 STR-RKHLGCAVFNNYIYAVGGRDDCME-----LSSAERYNPLTNTWSPIVAMTSRRSGVGLAVV 556
            .|. ..|:..|| :|.|||.||..:.:.     :.....|:..|||||....:.:.:...|:..:
  Fly   492 PTPCCDHVLVAV-DNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAM 555

  Fly   557 NGQLYAVGGFDGS-----AYLKTIEVYDPETNQW 585
            ...::.|||.|.:     |..:|: .||.:|.:|
  Fly   556 GRTIFFVGGLDSTESIDRASAETM-AYDLDTKEW 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	46/127 (36%)
		PHA03098	69..587	CDD:222983	153/567 (27%)
		KELCH repeat	359..403	CDD:276965	17/47 (36%)
		KELCH repeat	407..451	CDD:276965	17/49 (35%)
		KELCH repeat	454..497	CDD:276965	11/42 (26%)
		KELCH repeat	501..545	CDD:276965	15/48 (31%)
		KELCH repeat	548..593	CDD:276965	11/43 (26%)
CG1812	NP_608397.1	BTB	38..142	CDD:279045	41/103 (40%)
		PHA03098	46..588	CDD:222983	152/564 (27%)
		BACK	151..249	CDD:285009	19/97 (20%)
		KELCH repeat	344..390	CDD:276965	17/46 (37%)
		KELCH repeat	394..444	CDD:276965	18/50 (36%)
		Kelch	406..458	CDD:128874	16/51 (31%)
		Kelch_1	448..492	CDD:279660	11/43 (26%)
		KELCH repeat	448..492	CDD:276965	11/43 (26%)
		Kelch_1	494..539	CDD:279660	14/45 (31%)
		KELCH repeat	495..539	CDD:276965	14/44 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	4	3.960