DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and CG17754

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	250/614 - (40%)
Similarity:	350/614 - (57%)	Gaps:	59/614 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TAVDRPPSPARLSHTSEK-HPKV----TLTEL--------------------------NMLRR-- 67
            :||::..||:|.|..|.. |..:    ||..|                          |:|:|
  Fly     2 SAVNQKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQ 66

  Fly    68 ----HRELCDVVLNVG--GRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELL 126
                .::||||||..|  |:::.|||::|||.|:||.|||||.|.|:::.|||:.::..:|:.||
  Fly    67 LYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLL 131

  Fly   127 IDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLR 191
            :.:|||..|.:.|..|:|||..||||||..:...||.||.|||.|:||||...||:..||..|||
  Fly   132 VQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLR 196

  Fly   192 IADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQ 256
            :|..:|...|.:|.:::||..|...||..::.||:|||.||:.||:::|||::::.|.|.||:.:
  Fly   197 LAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPE 261

  Fly   257 VLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRG 321
            :|..||||||.|.|::..|.:   |.:...|:.||.||..:.|:|:.|..:...||.|||.| .|
  Fly   262 LLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKST-VG 322

  Fly   322 EVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSI 386
            .:| ||||..:.....|:|.:.|:.:.|.....|:.||...|.||:.|.|..|||.||...||::
  Fly   323 RLL-AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTV 386

  Fly   387 ERYDPQTNQWSCDVAPTTSCRT---SVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVA 448
            |..|..|..|    ||..:..|   .:|||||:|.||||||.||...||.|||:||....||.||
  Fly   387 ESLDLNTMAW----APLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVA 447

  Fly   449 PMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYI 513
            ||::.|....||||||.|||:||.||.....::|.|||..|||..::||:.||..:|..|.|.::
  Fly   448 PMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFL 512

  Fly   514 YAVGGRDDC-------MELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAY 571
            ||:||. ||       ....:.|||:|.|:||:.|.::...|..:|.|::..:|..|||:||:..
  Fly   513 YALGGH-DCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHA 576

  Fly   572 LKTIEVYDPETNQWRLCGCMNYRRLGGGV 600
            ||::|.|||..|.|.....|.:.|.|..|
  Fly   577 LKSVEEYDPVRNGWNELAPMAFARAGACV 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	63/165 (38%)
		PHA03098	69..587	CDD:222983	232/529 (44%)
		KELCH repeat	359..403	CDD:276965	18/43 (42%)
		KELCH repeat	407..451	CDD:276965	27/46 (59%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	18/50 (36%)
		KELCH repeat	548..593	CDD:276965	18/44 (41%)
CG17754	NP_572549.2	BTB	70..170	CDD:279045	47/99 (47%)
		PHA03098	71..591	CDD:222983	231/529 (44%)
		BACK	179..281	CDD:285009	44/101 (44%)
		Kelch	323..369	CDD:128874	15/46 (33%)
		KELCH repeat	359..402	CDD:276965	19/46 (41%)
		Kelch	370..416	CDD:128874	20/49 (41%)
		KELCH repeat	406..449	CDD:276965	25/42 (60%)
		Kelch	418..463	CDD:128874	26/44 (59%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	18/47 (38%)
		KELCH repeat	500..549	CDD:276965	18/49 (37%)
		KELCH repeat	553..596	CDD:276965	17/42 (40%)
		Kelch	564..610	CDD:128874	18/42 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464369
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26788at33392
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	10	9.900