DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and Klhl4

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001101714.1	Gene:	Klhl4 / 317196	RGDID:	1565441	Length:	717	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	239/562 - (42%)
Similarity:	349/562 - (62%)	Gaps:	10/562 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEV 113
            :.|..|...||.::....:.::||||:|..|..||.|||::|||.|.||.||||.::.|:||.||
  Rat   158 YRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEV 222

  Fly   114 TIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIR 178
            .:..:|.||:..|:.:.||..:.:.|..::.||.|||||||.::.|:||.||.:||.|:||||||
  Rat   223 KMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIR 287

  Fly   179 AFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWL 243
            :|.|...|.||..:|.|:|..:|.:|::::||||||..::..::|||::||..||.:|:|:|.|:
  Rat   288 SFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWV 352

  Fly   244 KYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQ 308
            .::...|:|.||::|.::|||||||:.|.....|.:. ..|..|:.|:.||..|.|||:.|.::|
  Rat   353 GHDAQARQQDLAKLLSYIRLPLLSPQLLADLENSSMF-SGDLECQKLLMEAMKYHLLPERRSMLQ 416

  Fly   309 GPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYA 373
            .|||:|||.|  ...|:||||..:.....::|::|.:||.|..:..||.||...||||:::.||.
  Rat   417 SPRTKPRKST--VGALYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSGRRLQFGVAVVDNKLYV 479

  Fly   374 VGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYD 438
            |||.||...||::|.::|.|..|.. :.|.::.|..:|||.|:|.:|||||.||...||.|||:|
  Rat   480 VGGRDGLKTLNTVECFNPVTKTWVV-MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWD 543

  Fly   439 PKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKH 503
            |...:|:.||.|:|.|..|.|..|...||||||.||...|.::|.:||..|||...:|||.||..
  Rat   544 PDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGG 608

  Fly   504 LGCAVFNNYIYAVGGRD-----DCMELSS-AERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYA 562
            :|.|..|.|:|.|||.|     .|..||. .|||:|.:::||.:..::..|..|.:..:..:||.
  Rat   609 VGVATHNGYLYVVGGHDAPAPNHCSRLSDCVERYDPKSDSWSTVAPLSVPRDAVAVCPLGDKLYV 673

  Fly   563 VGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMR 604
            |||:||..||.|:|.||.:.::|:....:|..|.|..|.|::
  Rat   674 VGGYDGHTYLNTVESYDAQKDEWKEEVPVNIGRAGACVVVVK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	56/126 (44%)
		PHA03098	69..587	CDD:222983	230/523 (44%)
		KELCH repeat	359..403	CDD:276965	18/43 (42%)
		KELCH repeat	407..451	CDD:276965	23/43 (53%)
		KELCH repeat	454..497	CDD:276965	19/42 (45%)
		KELCH repeat	501..545	CDD:276965	19/49 (39%)
		KELCH repeat	548..593	CDD:276965	16/44 (36%)
Klhl4	NP_001101714.1	BTB	171..275	CDD:279045	46/103 (45%)
		PHA03098	175..697	CDD:222983	229/525 (44%)
		BACK	283..382	CDD:285009	45/98 (46%)
		Kelch	430..475	CDD:128874	18/44 (41%)
		Kelch_1	464..509	CDD:279660	20/45 (44%)
		KELCH repeat	465..508	CDD:276965	18/43 (42%)
		KELCH repeat	512..556	CDD:276965	23/43 (53%)
		Kelch	525..569	CDD:128874	23/43 (53%)
		KELCH repeat	559..602	CDD:276965	19/42 (45%)
		Kelch	570..616	CDD:128874	22/45 (49%)
		Kelch_1	605..656	CDD:279660	20/50 (40%)
		KELCH repeat	606..657	CDD:276965	19/50 (38%)
		KELCH repeat	659..698	CDD:276965	16/38 (42%)
		Kelch	670..714	CDD:128874	18/43 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820