DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and Klhl18

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006244067.1	Gene:	Klhl18 / 316012	RGDID:	1310570	Length:	579	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	236/544 - (43%)
Similarity:	337/544 - (61%)	Gaps:	9/544 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF 129
            :||..:||||.|.:|..|..|||::|:|...||.||||.::.|.:|.|:.::.:|.:|:|.||:|
  Rat    31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINF 95

  Fly   130 CYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIAD 194
            .|..::.:::.|||:||..|..|||..|:|.||.||:.:|.|.||||:|.||:|..|..|...|:
  Rat    96 AYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAAN 160

  Fly   195 KFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQ 259
            .|...:|.||..|||||.||:..:::::..|||||:||||||.|.::|::|:..:|...|.::|.
  Rat   161 SFIHQHFVEVSLSEEFLALPLEDVLELLSRDELNVKSEEQVFEAALAWIRYDREQRGPCLPELLS 225

  Fly   260 HVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVL 324
            ::||||..|:||...|..|.|||....|||||||||:|.|:|:.||.:...|||||..|....::
  Rat   226 NIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLI 290

  Fly   325 FAVGG------WCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYL 383
            :||||      :.:||::..||.|||..|.|:...||:..|..|||||:|.||||:||:|||..|
  Rat   291 YAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRL 355

  Fly   384 NSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVA 448
            :::|.|:|:|:.|: .|....|.|:::|..||||.:|..||.||...||.||.|.|:.:||:.|.
  Rat   356 STVEAYNPETDTWT-RVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVT 419

  Fly   449 PMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYI 513
            ||::.|....|.|..|.:|..||.||....::||:|:.....|...:.|..:|...|.|...:.:
  Rat   420 PMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEQYNHHTATWHPAASMLNKRCRHGAASLGSKM 484

  Fly   514 YAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVY 578
            :..||.|....||.||.|:.:.:.|..||.|.:|||.|.|....|:||||||:||.:.|.::|:|
  Rat   485 FVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMY 549

  Fly   579 DPETNQWRLCGCMNYRRLGGGVGV 602
            ||||::|.....|....  |||||
  Rat   550 DPETDRWTFMAPMACHE--GGVGV 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	49/110 (45%)
		PHA03098	69..587	CDD:222983	228/523 (44%)
		KELCH repeat	359..403	CDD:276965	23/43 (53%)
		KELCH repeat	407..451	CDD:276965	21/43 (49%)
		KELCH repeat	454..497	CDD:276965	13/42 (31%)
		KELCH repeat	501..545	CDD:276965	14/43 (33%)
		KELCH repeat	548..593	CDD:276965	22/44 (50%)
Klhl18	XP_006244067.1	BTB	28..131	CDD:279045	43/99 (43%)
		PHA03098	34..557	CDD:222983	227/523 (43%)
		BACK	140..242	CDD:285009	45/101 (45%)
		KELCH repeat	282..327	CDD:276965	14/44 (32%)
		Kelch	289..341	CDD:128874	21/51 (41%)
		Kelch_1	330..375	CDD:279660	23/45 (51%)
		KELCH repeat	331..374	CDD:276965	23/43 (53%)
		KELCH repeat	378..422	CDD:276965	21/43 (49%)
		Kelch	389..435	CDD:128874	19/45 (42%)
		KELCH repeat	425..469	CDD:276965	13/43 (30%)
		Kelch	436..481	CDD:128874	13/44 (30%)
		KELCH repeat	472..516	CDD:276965	14/43 (33%)
		Kelch_1	472..515	CDD:279660	14/42 (33%)
		Kelch_1	518..562	CDD:279660	22/43 (51%)
		KELCH repeat	519..562	CDD:276965	21/42 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930