DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and Ivns1abp

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006250050.1	Gene:	Ivns1abp / 289089	RGDID:	1306290	Length:	642	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	188/633 - (29%)
Similarity:	303/633 - (47%)	Gaps:	100/633 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQT 111
            |....|...:.::.:||.||:..:.|||.|.|.|.::.|||.:|:.||.|...:|..:.:....:
  Rat     7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGVS 71

  Fly   112 EVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLG 176
            .|.:.|::..|:|:|:::.|||.:..::..|:.:..||..|::..::.:|.::|..::|.|:|:.
  Rat    72 HVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136

  Fly   177 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMS 241
            .|.||.......||...|.:.|.:..::.|.||||.||..:| :::..|.:.:.|..:::..|::
  Rat   137 YRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200

  Fly   242 WLKYNVAERRQHLAQVLQHVRL-------------PL---------------------------- 265
            |::.::.|....|.::::.|:.             ||
  Rat   201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHK 265

  Fly   266 -----------------LSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLL-----PQERP--- 305
                             .|||.....|.|:....:...|..::|.....:.|     ||..|
  Rat   266 QISGSSTGCLSSPNASVQSPKHEWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSPQSSPTST 330

  Fly   306 ---------------LMQGPRTRPRKPTRRG----EV---LFAVGGWCSGDAIASVERFDPQTND 348
                           |::.|.: |.:..|.|    |:   |.|.||:...:.:.:||.:||.|:.
  Rat   331 PKLSKSLSFEMQPDELLEKPMS-PMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDH 394

  Fly   349 WKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQS-YLNSIERYDPQTNQWSCDVAPTTSCRT---S 409
            |..:|||...|....:|||...||.|||.:|.| .|:..|.|||..:.|:    |....||   :
  Rat   395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPSIDDWT----PVPELRTNRCN 455

  Fly   410 VGVAVLDGFLYAVGGQD--GVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGS 472
            .||..|:|.||.|||.|  |.:.|.:.:.:||....|:..||:..||...||..|||:||.|||:
  Rat   456 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520

  Fly   473 DGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNT 537
            :....|||||||:|.:|.|..::||:..|:..|.||.:..::..||.|....:|..|.|:|..|.
  Rat   521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNE 585

  Fly   538 WSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQW 585
            |..:..|||.||..|:..|...:||||||||:.:|.|:|||:.|:|:|
  Rat   586 WKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	36/126 (29%)
		PHA03098	69..587	CDD:222983	182/611 (30%)
		KELCH repeat	359..403	CDD:276965	17/44 (39%)
		KELCH repeat	407..451	CDD:276965	19/48 (40%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	13/43 (30%)
		KELCH repeat	548..593	CDD:276965	20/38 (53%)
Ivns1abp	XP_006250050.1	BTB_POZ_NS1BP	14..137	CDD:349615	35/122 (29%)
		PHA03098	23..638	CDD:222983	185/617 (30%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	25/96 (26%)
		KELCH repeat	358..401	CDD:276965	14/42 (33%)
		KELCH repeat	405..450	CDD:276965	18/48 (38%)
		KELCH repeat	453..498	CDD:276965	16/44 (36%)
		KELCH repeat	502..546	CDD:276965	22/43 (51%)
		KELCH repeat	549..592	CDD:276965	13/42 (31%)
		KELCH repeat	596..635	CDD:276965	20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820