DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and Klhl17

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006239583.1	Gene:	Klhl17 / 246757	RGDID:	708444	Length:	650	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	287/635 - (45%)
Similarity:	388/635 - (61%)	Gaps:	49/635 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QP---RDAAVTGTGGNSTAGGGSSVGSTAVDRPPSP---------AR------------------ 46
            ||   |.|..|.:..:|:.|.|..  :....:||:|         ||
  Rat     2 QPRGERPAGRTQSPEHSSPGPGPE--APPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHS 64

  Fly    47 LSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQT 111
            ::|.|::|.......::.:|:...|||:||:|..::|.||:|:|::||.||.||||.|:.|||||
  Rat    65 VAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQT 129

  Fly   112 EVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLG 176
            .||:.|||..|::.|:.|.|||.|:|.|.|||||||||.||||..::|.||:||..||||:||||
  Rat   130 HVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 194

  Fly   177 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMS 241
            ||.|||||||.:||:.|.::...:|.:|.::|||:|||:.|:::::.||.|||.|||.|:.||:|
  Rat   195 IRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLS 259

  Fly   242 WLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPL 306
            |:|::|..||||:.::::.|||||||..||:|.|.::.|||....|:||:.||..:.|||::|.:
  Rat   260 WVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGV 324

  Fly   307 MQGPRTRPRKPTRRGEVLFAVGGWCSGDAIA---SVERFDPQTNDWKMVAPMSKRRCGVGVAVLN 368
            :...|||||:....|.|||||||   |...|   ..|.:|.:|:.|.:||.||.||..||||.:.
  Rat   325 LGTSRTRPRRCEGAGPVLFAVGG---GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVG 386

  Fly   369 DLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNH 433
            :.||||||:||.|.|.::|.|||.||.|..:|:..|. |:.:|||.|.|.|||.||.||..|||.
  Rat   387 NRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTR-RSCLGVAALHGLLYAAGGYDGASCLNS 450

  Fly   434 VERYDPKENKWSKVAPMTTRRLGVAVAVLG----------GFLYAIGGSDGQCPLNTVERYDPRH 488
            .|||||....|:.:|.|:|||..|.||.||          |.|||:||.|....|.|||:|:|:.
  Rat   451 AERYDPLTGTWTSIAAMSTRRRYVRVATLGASWVYCLPTDGNLYAVGGYDSSSHLATVEKYEPQV 515

  Fly   489 NKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGL 553
            |.|..|:.|.:||...|.||....:|..||.|....|:|.|||:.....|..:..|..|||...|
  Rat   516 NSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDL 580

  Fly   554 AVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVM 603
            ..::|.||||||.|||:.|.:||.|:|.||:|....||..||...||.|:
  Rat   581 VAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	67/126 (53%)
		PHA03098	69..587	CDD:222983	263/530 (50%)
		KELCH repeat	359..403	CDD:276965	23/43 (53%)
		KELCH repeat	407..451	CDD:276965	23/43 (53%)
		KELCH repeat	454..497	CDD:276965	22/52 (42%)
		KELCH repeat	501..545	CDD:276965	14/43 (33%)
		KELCH repeat	548..593	CDD:276965	23/44 (52%)
Klhl17	XP_006239583.1	BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	63/137 (46%)
		PHA03098	90..566	CDD:222983	238/479 (50%)
		BACK	187..288	CDD:421692	54/100 (54%)
		KELCH repeat	377..420	CDD:276965	23/42 (55%)
		KELCH repeat	424..468	CDD:276965	23/43 (53%)
		KELCH repeat	471..526	CDD:276965	23/54 (43%)
		KELCH repeat	528..572	CDD:276965	14/43 (33%)
		KELCH repeat	575..620	CDD:276965	23/44 (52%)
		Kelch	587..631	CDD:128874	24/44 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830