Protein Alignment dbo and Klhl12

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001298065.1
• Gene: Klhl12 / 240756
• MGIID: 2385619
• Length: 568
• Species: Mus musculus
• Alignment Length: 555
• Identity: 244/555 - (43%)
• Similarity: 347/555 - (62%)
• Gaps: 7/555 - (1%)

  Fly    54 HPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDI 118
            |.|..|..:|.||:...||||.|.|..:...|||::|:|||.|||||||.||.|..:..|.|:.:
Mouse    15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGL 79

  Fly   119 DENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADT 183
            ....||:|:||.||..:.|...|||.||||||||||..::..|||||:.||||:||||||.||:|
Mouse    80 TAATMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAET 144

  Fly   184 HSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVA 248
            |:|.:|::.|:.|:|.:|.||::.|||:||..|::..:|..||:.|.|||.||.||::|:|:...
Mouse   145 HNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKK 209

  Fly   249 ERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTR 313
            ||.:.|..:||:||:|||:|:::...:.::..:|....|||||||||.:.|.|:.|..|||||||
Mouse   210 EREESLPDLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTR 274

  Fly   314 PRKPTRRGEVLFAVGGWCSGDA-IASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGH 377
            .|  ....|||..|||:.|..: |..||::||:|.:|..:..::::|..|....|:|.:|.:||:
Mouse   275 AR--LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY 337

  Fly   378 DGQSYLNSIERYDPQTNQ---WSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDP 439
            ||:|.|:|:|..|...::   | ..|||....|...|...|...:|..||.||.:....:|||||
Mouse   338 DGRSRLSSVECLDYTADEDGVW-YSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDP 401

  Fly   440 KENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHL 504
            ..::||.:..|.|.|.|..:.|..|.:|.:||.||...||:||:|||....|..|:||:|:|...
Mouse   402 NIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGA 466

  Fly   505 GCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGS 569
            |.|:.|::||.|||.|....|||.|.||..|::|:.:.:||:.|..||..|:.|:|||:.|:||:
Mouse   467 GVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN 531

  Fly   570 AYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMR 604
            :.|.:||.|||..:.|.:...|..:|...||.|:|
Mouse   532 SLLSSIECYDPIIDSWEVVASMGTQRCDAGVCVLR 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	63/121 (52%)
		PHA03098	69..587	CDD:222983	232/521 (45%)
		KELCH repeat	359..403	CDD:276965	17/46 (37%)
		KELCH repeat	407..451	CDD:276965	15/43 (35%)
		KELCH repeat	454..497	CDD:276965	18/42 (43%)
		KELCH repeat	501..545	CDD:276965	18/43 (42%)
		KELCH repeat	548..593	CDD:276965	19/44 (43%)
Klhl12	NP_001298065.1	BTB_POZ_KLHL12_C3IP1_DKIR	12..135	CDD:349551	61/119 (51%)
		BACK_KLHL12	130..265	CDD:350527	63/134 (47%)
		KELCH repeat	274..315	CDD:276965	16/42 (38%)
		Kelch	282..329	CDD:128874	16/46 (35%)
		Kelch 1	282..329		16/46 (35%)
		NanM	308..565	CDD:442289	99/257 (39%)
		KELCH repeat	319..365	CDD:276965	17/46 (37%)
		Kelch 2	331..379		17/48 (35%)
		KELCH repeat	369..412	CDD:276965	15/42 (36%)
		Kelch 3	380..426		17/45 (38%)
		Interaction with DVL3. /evidence=ECO:0000250	405..568		69/162 (43%)
		KELCH repeat	416..459	CDD:276965	18/42 (43%)
		KELCH repeat	463..507	CDD:276965	18/43 (42%)
		KELCH repeat	510..555	CDD:276965	19/44 (43%)