DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and Klhl4

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_766369.2	Gene:	Klhl4 / 237010	MGIID:	2442829	Length:	717	Species:	Mus musculus

Alignment Length:	612	Identity:	248/612 - (40%)
Similarity:	360/612 - (58%)	Gaps:	18/612 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GDLPGSGSTAQPRDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLS---HTSEKHPKVTLTELN 63
            |:|.......:.||..:.|.........|     ..|:.|......|   :.|..|...||.::.
Mouse   113 GNLLKEACEKRSRDLEMMGDDNIEDMRAG-----PCVEEPEQMTTSSNDHYRSRSHADYTLCKME 172

  Fly    64 MLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLID 128
            ...:.|:||||:|..|..||.|||::|||.|.||.||||.::.|:||.||.|..:|.||:..|:.
Mouse   173 SYLKERKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKIEGVDPNALNSLVQ 237

  Fly   129 FCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIA 193
            :.||..:.:.|..::.||.|||||||.::.|:||.||.:||.|:||||||:|.|...|.||..:|
Mouse   238 YAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIRSFGDAQGCMELQNVA 302

  Fly   194 DKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVL 258
            .|:...:|.:|::::||||||..::..::|||::||..||.:|:|:|.|:.::...|::.||::|
Mouse   303 HKYAMEHFIDVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDAQARQRDLAKLL 367

  Fly   259 QHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEV 323
            .::|||||||:.|.....|.....:.| |:.|:.||..|.|||:.|.::|.|||:|||.|  ...
Mouse   368 SYIRLPLLSPQLLADLENSSFFSGNLE-CQKLLMEAMKYHLLPERRSMLQSPRTKPRKST--VGA 429

  Fly   324 LFAVGGWCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIER 388
            |:||||..:.....::|::|.:||.|..:..||.||...||||:::.||.|||.||...||::|.
Mouse   430 LYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSGRRLQFGVAVVDNKLYVVGGRDGLKTLNTVEC 494

  Fly   389 YDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTR 453
            ::|.|..|.. :.|.::.|..:|||.|:|.:|||||.||...||.|||:||...:|:.||.|:|.
Mouse   495 FNPVTKTWVV-MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTP 558

  Fly   454 RLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGG 518
            |..|.|..|...||||||.||...|.::|.:||..|||...:|||.||..:|.|..|.|:|.|||
Mouse   559 RSTVGVVALNNRLYAIGGRDGSSCLKSMEFFDPHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGG 623

  Fly   519 RD-----DCMELSS-AERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEV 577
            .|     .|..||. .|||:|..::||.:..::..|..|.:..:..:||.|||:||..||.|:|.
Mouse   624 HDAPAPNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVES 688

  Fly   578 YDPETNQWRLCGCMNYRRLGGGVGVMR 604
            ||.:.::|:....:|..|.|..|.|::
Mouse   689 YDAQKDEWKEEVPVNIGRAGACVVVVK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	58/126 (46%)
		PHA03098	69..587	CDD:222983	230/523 (44%)
		KELCH repeat	359..403	CDD:276965	18/43 (42%)
		KELCH repeat	407..451	CDD:276965	23/43 (53%)
		KELCH repeat	454..497	CDD:276965	19/42 (45%)
		KELCH repeat	501..545	CDD:276965	19/49 (39%)
		KELCH repeat	548..593	CDD:276965	16/44 (36%)
Klhl4	NP_766369.2	BTB	171..275	CDD:279045	48/103 (47%)
		PHA03098	175..697	CDD:222983	229/525 (44%)
		BACK	283..382	CDD:285009	43/98 (44%)
		Kelch	430..475	CDD:128874	18/44 (41%)
		Kelch_1	464..509	CDD:279660	20/45 (44%)
		KELCH repeat	465..508	CDD:276965	18/43 (42%)
		KELCH repeat	512..556	CDD:276965	23/43 (53%)
		Kelch	525..569	CDD:128874	23/43 (53%)
		KELCH repeat	559..602	CDD:276965	19/42 (45%)
		Kelch	570..616	CDD:128874	22/45 (49%)
		Kelch_1	605..656	CDD:279660	20/50 (40%)
		KELCH repeat	606..657	CDD:276965	19/50 (38%)
		KELCH repeat	659..698	CDD:276965	16/38 (42%)
		Kelch	670..714	CDD:128874	18/43 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820