Protein Alignment dbo and Klhl36

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_666331.1
• Gene: Klhl36 / 234796
• MGIID: 2385305
• Length: 613
• Species: Mus musculus
• Alignment Length: 587
• Identity: 175/587 - (29%)
• Similarity: 277/587 - (47%)
• Gaps: 62/587 - (10%)

  Fly    40 RPPSPARLSHTSE-----KHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCA 99
            |...|.::|.:|:     .|....|..||..|.|...|||||.|..:::.|||.:|:.||.||.:
Mouse     8 RVSRPYKISESSKVYHWPDHSTAVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLLAVCSDYFNS 72

  Fly   100 MFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEF 164
            |||..:.|:.|.||.:.......::.::||.|::.:.::.||:..:|..|.|||:..:.|.|||:
Mouse    73 MFTLGMREAFQKEVELVGTSYVGLKAVVDFLYSSELELDGSNIDYILETAHLLQIWTVVDFCCEY 137

  Fly   165 LKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFL-LLPVGQLVDIICSDELN 228
            |::::...|.|.::..|..:|.:.|....|.|...:|..:..:.:|| .:.|.:|...:.|.::.
Mouse   138 LEQEVSEDNYLYLQELASIYSLKRLDAFIDSFVLSHFSTLSFTPDFLQSISVQKLCVYLSSGQVQ 202

  Fly   229 VRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDL--LVRSDEACRDLV 291
            .:.|..:....:.||... .||..|..:||:::|.||.....|:..|...:  |:.|:......|
Mouse   203 HKWEYDLLQVALQWLTQQ-PEREVHTRRVLENIRFPLFPEDILLQRVKLAMCSLLPSEANGEGFV 266

  Fly   292 DEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVER----------FDPQT 346
            :||.:|......:|::|..||.    .|..|.|..|||..|       ||          .|.:.
Mouse   267 EEAMHYHNSLVAQPVLQTKRTL----LRSEECLLFVGGEVS-------ERCLELSDDTCYLDTKN 320

  Fly   347 NDWKMVAPMSKRRCGVGVAVLNDLLYAVGG-----HDGQSYLNSIERYDPQTNQWSCDVAPTTSC 406
            ..|.....:..||....||||...::..||     :.|.:..|.:.||||:..|| ..||.....
Mouse   321 EQWVKETSLPARRSHHCVAVLGGFIFIAGGSFSRDNGGNAASNLLYRYDPRRKQW-IKVASMNQR 384

  Fly   407 RTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGG 471
            |....:|.::..|.||||::....|:.||.|.||.|.|:.||.:.....|.|..:...|:|..||
Mouse   385 RVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFVYISGG 449

  Fly   472 SDGQ---------CPLNTVERYDPRHNKWVAVSPMSTRRK-HLGCAVFNNYIYAVGGRDDCME-- 524
            .|.|         |       ||.|.:.|....||:|.|. |..|:: .:.||::||.||.||
Mouse   450 HDYQIGPYRKNLLC-------YDHRTDVWEERRPMTTARGWHSMCSL-GDSIYSIGGSDDHMESM 506

  Fly   525 ----LSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGF--DGSAYLKTIEVYDPETN 583
                :...|.|:|..|.|:.:..:....|..|:||..|::|.:||:  :.:|:.:.::|||.|.|
Mouse   507 ERFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWESTAFSRAVQVYDSEAN 571

  Fly   584 QW 585
            :|
Mouse   572 RW 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	44/131 (34%)
		PHA03098	69..587	CDD:222983	165/553 (30%)
		KELCH repeat	359..403	CDD:276965	17/48 (35%)
		KELCH repeat	407..451	CDD:276965	17/43 (40%)
		KELCH repeat	454..497	CDD:276965	13/51 (25%)
		KELCH repeat	501..545	CDD:276965	16/50 (32%)
		KELCH repeat	548..593	CDD:276965	15/40 (38%)
Klhl36	NP_666331.1	BTB_POZ	20..154	CDD:453885	44/133 (33%)
		BACK	142..240	CDD:475122	24/98 (24%)
		Kelch 1	294..343		15/55 (27%)
		NanM	322..590	CDD:442289	83/261 (32%)
		KELCH repeat	333..381	CDD:276965	17/48 (35%)
		Kelch 2	344..395		14/51 (27%)
		KELCH repeat	385..429	CDD:276965	17/43 (40%)
		Kelch 3	396..442		17/45 (38%)
		KELCH repeat	432..479	CDD:276965	15/53 (28%)
		Kelch 4	444..491		16/54 (30%)
		KELCH repeat	481..531	CDD:276965	16/50 (32%)
		Kelch 5	492..544		17/51 (33%)
		KELCH repeat	534..580	CDD:276965	15/40 (38%)
		Kelch 6	545..593		10/29 (34%)