DRSC/TRiP Functional Genomics Resources

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Protein Alignment dbo and KLHL18

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:XP_005265058.2 Gene:KLHL18 / 23276 HGNCID:29120 Length:584 Species:Homo sapiens


Alignment Length:548 Identity:233/548 - (42%)
Similarity:336/548 - (61%) Gaps:12/548 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF 129
            :||..:||||.|.:|..|..|||::|:|...||.||||.::.|.:|.|:.::.:|.:|:|.||:|
Human    31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINF 95

  Fly   130 CYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIAD 194
            .|..::.:::.|||:||..|..|||..|:|.||.||:.:|.|.||||:|.||:|..|..|...|:
Human    96 AYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAAN 160

  Fly   195 KFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQ 259
            .|...:|.||..|||||.||:..:::::..|||||:||||||.|.::|::|:..:|..:|.::|.
Human   161 SFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLS 225

  Fly   260 HVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVL 324
            ::||||..|:||...|..|.|||....|||||||||:|.|:|:.||.:...|||||..|....::
Human   226 NIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLI 290

  Fly   325 FAVGG------WCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYL 383
            :||||      :.:||::..||.|||..|.|:...||:..|..|||||:|.||||:||:|||..|
Human   291 YAVGGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRL 355

  Fly   384 NSIERYDPQTNQW----SCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKW 444
            :::|.|:|:|:.|    |.:...::.|.:::|..||||.:|..||.||...|:.||.|.|:.:||
Human   356 STVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKW 420

  Fly   445 SKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVF 509
            :.|..|::.|....|.|..|.:|..||.||....::||.|:.....|...:.|..:|...|.|..
Human   421 TVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASL 485

  Fly   510 NNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKT 574
            .:.::..||.|....||.||.|:.:.:.|..||.|.:|||.|.|....|:||||||:||.:.|.:
Human   486 GSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS 550

  Fly   575 IEVYDPETNQWRLCGCMNYRRLGGGVGV 602
            :|:|||||:.|.....|....  |||||
Human   551 VEMYDPETDCWTFMAPMACHE--GGVGV 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 49/110 (45%)
PHA03098 69..587 CDD:222983 225/527 (43%)
KELCH repeat 359..403 CDD:276965 23/47 (49%)
KELCH repeat 407..451 CDD:276965 18/43 (42%)
KELCH repeat 454..497 CDD:276965 13/42 (31%)
KELCH repeat 501..545 CDD:276965 14/43 (33%)
KELCH repeat 548..593 CDD:276965 22/44 (50%)
KLHL18XP_005265058.2 BTB 28..131 CDD:279045 43/99 (43%)
PHA03098 34..562 CDD:222983 224/527 (43%)
BACK 140..242 CDD:285009 45/101 (45%)
KELCH repeat 282..327 CDD:276965 14/44 (32%)
Kelch 289..341 CDD:128874 21/51 (41%)
Kelch_1 330..375 CDD:279660 23/44 (52%)
KELCH repeat 331..374 CDD:276965 22/42 (52%)
KELCH repeat 378..427 CDD:276965 19/48 (40%)
Kelch 394..440 CDD:128874 17/45 (38%)
KELCH repeat 430..474 CDD:276965 13/43 (30%)
Kelch 441..486 CDD:128874 13/44 (30%)
KELCH repeat 477..521 CDD:276965 14/43 (33%)
Kelch_1 477..520 CDD:279660 14/42 (33%)
Kelch_1 523..567 CDD:279660 22/43 (51%)
KELCH repeat 524..567 CDD:276965 21/42 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59391
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.830

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