DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dbo and Klhl17

DIOPT Version :9

Sequence 1:NP_524989.2 Gene:dbo / 53556 FlyBaseID:FBgn0040230 Length:623 Species:Drosophila melanogaster
Sequence 2:NP_938047.1 Gene:Klhl17 / 231003 MGIID:2678948 Length:640 Species:Mus musculus


Alignment Length:625 Identity:286/625 - (45%)
Similarity:387/625 - (61%) Gaps:39/625 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 QP---RDAAVTGTGGNSTAGGGSSVGSTAVDRPPSP---------AR------------------ 46
            ||   |.|..|.:..:|:.|.|..  :....:||:|         ||                  
Mouse     2 QPRGERPAGRTQSPEHSSPGPGPE--APPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHS 64

  Fly    47 LSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQT 111
            ::|.|::|.......::.:|:...|||:||:|..::|.||:|:|::||.||.||||.|:.|||||
Mouse    65 VAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQT 129

  Fly   112 EVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLG 176
            .||:.|||..|::.|:.|.|||.|:|.|.|||||||||.||||..::|.||:||..||||:||||
Mouse   130 HVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 194

  Fly   177 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMS 241
            ||.|||||||.:||:.|.::...:|.:|.::|||:|||:.|:::::.||.|||.|||.|:.||:|
Mouse   195 IRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLS 259

  Fly   242 WLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPL 306
            |:|::|..||||:.::::.|||||||..||:|.|.::.|||....|:||:.||..:.|||::|.:
Mouse   260 WVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGV 324

  Fly   307 MQGPRTRPRKPTRRGEVLFAVGGWCSGDAIA---SVERFDPQTNDWKMVAPMSKRRCGVGVAVLN 368
            :...|||||:....|.|||||||   |...|   ..|.:|.:|:.|.:||.||.||..||||.:.
Mouse   325 LGTSRTRPRRCEGAGPVLFAVGG---GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVG 386

  Fly   369 DLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNH 433
            :.||||||:||.|.|.::|.|||.||.|..:|:..|. |:.:|||.|.|.|||.||.||..|||.
Mouse   387 NRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTR-RSCLGVAALHGLLYAAGGYDGASCLNS 450

  Fly   434 VERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMS 498
            .|||||....|:.:|.|:|||..|.||.|.|.|||:||.|....|.|||:|:|:.|.|..|:.|.
Mouse   451 AERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASML 515

  Fly   499 TRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAV 563
            :||...|.||....:|..||.|....|:|.|||:.....|..:..|..|||...|..::|.||||
Mouse   516 SRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAV 580

  Fly   564 GGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVM 603
            ||.|||:.|.:||.|:|.||:|....||..||...||.|:
Mouse   581 GGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dboNP_524989.2 BTB_POZ_KLHL20_KLEIP 49..176 CDD:349558 67/126 (53%)
PHA03098 69..587 CDD:222983 262/520 (50%)
KELCH repeat 359..403 CDD:276965 23/43 (53%)
KELCH repeat 407..451 CDD:276965 23/43 (53%)
KELCH repeat 454..497 CDD:276965 21/42 (50%)
KELCH repeat 501..545 CDD:276965 14/43 (33%)
KELCH repeat 548..593 CDD:276965 23/44 (52%)
Klhl17NP_938047.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 13/49 (27%)
BTB_POZ_KLHL17_actinfilin 51..189 CDD:349555 63/137 (46%)
PHA03098 90..556 CDD:222983 237/469 (51%)
BACK 187..288 CDD:421692 54/100 (54%)
Interaction with F-actin. /evidence=ECO:0000250 287..639 157/338 (46%)
KELCH repeat 377..420 CDD:276965 23/42 (55%)
KELCH repeat 424..468 CDD:276965 23/43 (53%)
KELCH repeat 471..516 CDD:276965 22/44 (50%)
KELCH repeat 518..562 CDD:276965 14/43 (33%)
KELCH repeat 565..610 CDD:276965 23/44 (52%)
Kelch 577..621 CDD:128874 24/44 (55%)
Interaction with PDZK1. /evidence=ECO:0000250 638..640
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59391
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.830

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