Protein Alignment dbo and Klhl14

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001074872.1
• Gene: Klhl14 / 225266
• MGIID: 1921249
• Length: 630
• Species: Mus musculus
• Alignment Length: 621
• Identity: 159/621 - (25%)
• Similarity: 269/621 - (43%)
• Gaps: 107/621 - (17%)

  Fly    46 RLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFT-------- 102
            |.|.....|....|..||:|.|.:..|||.|...|::...|:.:|::||.||.::|:
Mouse     7 RTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGG 71

  Fly   103 -------GELEESRQTE--------------------------------------VTIRDIDENA 122
                   |..::.:|.:                                      :.::......
Mouse    72 VGGQDGLGAPKDQQQQQQPQQQPPQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 136

  Fly   123 MELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCR 187
            :.|::::.|||::.:....|:.:|..:.:|.:.::..:|.:||..|:...|...:...|..|...
Mouse   137 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLE 201

  Fly   188 ELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQ 252
            |..::|:|:.         .|:.|||...::..::.|....|.||..:|...:.||:::...|.|
Mouse   202 ETKKLANKYL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQ 257

  Fly   253 HLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKP 317
            :...:::.:|..|:....||..|.|...:|:|..|:.|:.:|.||.|:|..:...|...:|.|.
Mouse   258 YAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRS- 321

  Fly   318 TRRGEVLFAVGGWCSG-DAIAS--VERFDPQTNDWKMVAPM---SKRRCGVGVAVLNDLLYAVGG 376
              ..::|..|||...| |.:.|  |:.:|.:...||::..|   |...|   |..:.:.|:.:||
Mouse   322 --NKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHC---VVEVENFLFVLGG 381

  Fly   377 HD-----GQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVER 436
            .|     |:...|.:.||||:.|.| ..:.|....|.|.....||..||.:||::....|:.||.
Mouse   382 EDQWNPNGKHSTNFVSRYDPRFNSW-IQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVEC 445

  Fly   437 YDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGG-SDGQ------CPLNTVERYDPRHNKWVAV 494
            |:...|:|..|:.:.......|.||..|.:|..|| .:|:      |       |||..:.|...
Mouse   446 YNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYC-------YDPVMDVWARK 503

  Fly   495 SPMSTRRKHLGCAVFNNYIYAVGGRD----DCMELSSAERYNPLTNTW----SPIVAMTSRRSGV 551
            ..|:|:|.....||.|:.:||:||..    ..:::...|.|:|..:.|    :||:   ..|||.
Mouse   504 QDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPIL---EGRSGP 565

  Fly   552 GLAVVNGQLYAVGGFDGS--AYLKTIEVYDPETNQW 585
            |.||::..:|.|||:..|  ||..:...|.||...|
Mouse   566 GCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	32/179 (18%)
		PHA03098	69..587	CDD:222983	151/598 (25%)
		KELCH repeat	359..403	CDD:276965	14/48 (29%)
		KELCH repeat	407..451	CDD:276965	15/43 (35%)
		KELCH repeat	454..497	CDD:276965	13/49 (27%)
		KELCH repeat	501..545	CDD:276965	14/51 (27%)
		KELCH repeat	548..593	CDD:276965	17/40 (43%)
Klhl14	NP_001074872.1	BTB_POZ_KLHL14_printor	1..190	CDD:349552	34/182 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..117		2/47 (4%)
		BACK_KLHL14	183..284	CDD:350528	25/109 (23%)
		Kelch 1	325..374		15/51 (29%)
		NanM	326..579	CDD:442289	80/266 (30%)
		KELCH repeat	365..412	CDD:276965	14/50 (28%)
		Kelch 2	375..426		16/51 (31%)
		KELCH repeat	416..460	CDD:276965	15/43 (35%)
		Kelch 3	427..473		14/45 (31%)
		KELCH repeat	463..508	CDD:276965	14/51 (27%)
		Kelch 4	475..520		14/51 (27%)
		Kelch 5	522..572		16/52 (31%)
		Kelch_1	562..604	CDD:396078	17/40 (43%)
		KELCH repeat	562..604	CDD:276965	17/40 (43%)
		Kelch 6	574..622		11/28 (39%)