DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and ivns-1

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_510109.1	Gene:	ivns-1 / 181410	WormBaseID:	WBGene00006493	Length:	817	Species:	Caenorhabditis elegans

Alignment Length:	656	Identity:	173/656 - (26%)
Similarity:	268/656 - (40%)	Gaps:	139/656 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQ------------- 110
            |..||..||:|||||.||.|..|:||.|:|:|:|.|.....||..|.|.|:.
Worm    81 LDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKSPTSSSPTNGH 145

  Fly   111 -----------------------------TEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLL 146
                                         |.......|....|.|::|.|||::.:....|..|.
Worm   146 TNGITNGNGEVAHENGAPVSAQKPQKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELY 210

  Fly   147 PAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVM-ESEEF 210
            ..|..||::.:...|..:|...|..:||:|||..|:.|:...|:...|:|...||..:: :|:||
Worm   211 KTAYALQMIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNDSKEF 275

  Fly   211 LLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVR----LPLLSPKFL 271
            ..|||.|:..|:.:::..|.:     ||..:.   .:||......|.:.|.|    :.||:.|..
Worm   276 TQLPVIQVRIIVPAEDGKVTN-----NANNNG---GLAEMALFYFQNMPHDRAEHSIDLLTCKTH 332

  Fly   272 V-----------------GTVGS-DLLVRSDEACRDLVDEAKNYLLLPQERPLMQG---PRTRPR 315
            :                 .:||| |::....::.:|..|.||   .:..:.|::..   .|....
Worm   333 ILYMEENHLADCIEMDERSSVGSCDIIQDYKKSGKDRKDVAK---AMTAQEPIINSVVQHRVNGA 394

  Fly   316 KPTR-----------RGEVLFAVGGWCSGDA---------IASVERFDPQTNDWKMVAPMSKRRC 360
            .|.|           ..|.|.:.|   :.|:         :.|..:..||.  |..:..:.:|.|
Worm   395 VPVRLNASRLPNMNASNESLESAG---TDDSDPQDTIEARLISTHQTAPQY--WVALVVLYRRLC 454

  Fly   361 GVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSC--------------RTSVG 411
            .:.:.:.          |.:..|.:.....|..:|.:..::...||              |.|:|
Worm   455 VLSLQLT----------DNEELLRTKREPCPVDSQKAALLSRLISCTGKQQKPLECMSAPRCSIG 509

  Fly   412 VAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQC 476
            .:.|:|.::..||.|..:||..||.||....||..||.|...|......:.||.::|:.||:|..
Worm   510 ASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNN 574

  Fly   477 PLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNT---- 537
            .|.:.|.|||:.:.|..:..::|.|.|.|||..:||:|.:||..|...|...||   |..|
Worm   575 DLKSCEIYDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCER---LDTTKLGT 636

  Fly   538 ----WSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGG 598
                |.|:.:|...|...|:....|.:.|.||.|....:.::|.:||:||.||....:...|.||
Worm   637 EEAEWEPMASMEHPRYQAGVCTWKGLVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGG 701

  Fly   599 GVGVMR 604
            .|.|:|
Worm   702 AVAVVR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	44/158 (28%)
		PHA03098	69..587	CDD:222983	161/627 (26%)
		KELCH repeat	359..403	CDD:276965	5/43 (12%)
		KELCH repeat	407..451	CDD:276965	18/43 (42%)
		KELCH repeat	454..497	CDD:276965	13/42 (31%)
		KELCH repeat	501..545	CDD:276965	18/51 (35%)
		KELCH repeat	548..593	CDD:276965	14/44 (32%)
ivns-1	NP_510109.1	BTB_POZ	77..241	CDD:365784	44/159 (28%)
		PHA03098	183..735	CDD:222983	146/554 (26%)
		KELCH repeat	505..548	CDD:276965	18/42 (43%)
		KELCH repeat	552..596	CDD:276965	13/43 (30%)
		KELCH repeat	599..647	CDD:276965	18/50 (36%)
		KELCH repeat	651..695	CDD:276965	14/43 (33%)
		KELCH repeat	698..743	CDD:276965	6/10 (60%)
		Kelch_1	744..>774	CDD:366584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820