DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and kel-10

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001366684.1	Gene:	kel-10 / 176423	WormBaseID:	WBGene00002186	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	607	Identity:	149/607 - (24%)
Similarity:	241/607 - (39%)	Gaps:	126/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SVGSTAVDRPP------------SPAR-------LSHTSEK--HPKVTLTELNMLRRHRELCDVV 75
            |....|...||            |||:       |:.:.|:  .|.|||    :||.:.|..|
Worm     7 SASQLATSPPPITTIDFNSSIEESPAKRVKFAPELTKSFEETLSPTVTL----VLRNNEETFD-- 65

  Fly    76 LNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF--CYTAHI--- 135
                       |.:||..|:||..:|:.:..:|:.|...||.|....:.||:..  .:...|
Worm    66 -----------RCLLSFYSNYFRVLFSSKFRDSKSTTHRIRLISAPDLHLLLTIPKAFEQGIKPN 119

  Fly   136 IVEESNVQTLLPAACL---LQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFT 197
            |..:..|:.|.|:|.|   :.|..|.|:.|..|..:    |.:.|...|..:.....:|:.....
Worm   120 ISLQKAVELLEPSAFLQMSIPLDYITDVICANLTHE----NIIKIFRLALLYHTTLAVRVWRAMV 180

  Fly   198 QHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVR 262
            : .||.:..:..:|.|...:|:.::....||::|.::. ..|::|:|:|...:...:||..|.
Worm   181 R-KFQTLFATNVYLTLKENELIGLLTDKHLNLKSADEK-TVVVNWIKHNSPLQSDRMAQFAQR-- 241

  Fly   263 LPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAV 327
                                  ...|....:|..|.::...:|:               :.:...
Worm   242 ----------------------NFSRQPQPDATKYEVIRTRQPM---------------DAIVCF 269

  Fly   328 GGWCSGDAIASVERFDPQTNDWKMV-----APMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIE 387
            |||.|.....::|.|:.:::.|:..     .| :.||...|:.|:.|.|...||.:|.....:..
Worm   270 GGWASRGVAQNIEVFNTRSDRWQTCNFNYDIP-NIRRAYHGIEVVEDKLIVYGGFNGTQQFQTTV 333

  Fly   388 RYDPQTNQW---------SCDVAPTTSCRTSVGVAVLDG----FLYAVGGQDGVQCLNHVERYDP 439
            .:|..|.:|         .|.|   ||.|      :.|.    .::|.||.:||..|...|.||.
Worm   334 LFDLSTKEWRSGANMNDKRCYV---TSAR------INDSHGRPLIFACGGMNGVSRLKTAEMYDY 389

  Fly   440 KENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSP-MSTRRKH 503
            :.::||:||.|...|...||..:...:..|||.||:......|.|||..:.|..:|. |.|||
Worm   390 RADQWSEVANMAQMRSDGAVVTIDNKIVVIGGFDGRNIHQGGEVYDPVLDLWHPLSSNMRTRR-- 452

  Fly   504 LGC---AVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNG-QLYAVG 564
            .||   ::.|.....:||.:....|.|||.|:.....|.|:.::.:.||......::. .:|..|
Worm   453 TGCTAVSIMNQVCMIIGGFNGNRRLDSAEIYDMREGLWHPVPSLHTARSNFSACQMDTCSIYVAG 517

  Fly   565 GFDGSAYLKTIEVYDPETNQWR 586
            ||||.|..|..|..|..:..|:
Worm   518 GFDGQATTKESERLDLRSKMWQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	36/136 (26%)
		PHA03098	69..587	CDD:222983	134/549 (24%)
		KELCH repeat	359..403	CDD:276965	13/52 (25%)
		KELCH repeat	407..451	CDD:276965	15/47 (32%)
		KELCH repeat	454..497	CDD:276965	14/43 (33%)
		KELCH repeat	501..545	CDD:276965	13/46 (28%)
		KELCH repeat	548..593	CDD:276965	13/40 (33%)
kel-10	NP_001366684.1	PHA03098	68..553	CDD:222983	131/529 (25%)
		KELCH repeat	305..348	CDD:276965	11/42 (26%)
		KELCH repeat	352..401	CDD:276965	19/57 (33%)
		KELCH repeat	404..446	CDD:276965	13/41 (32%)
		KELCH repeat	452..498	CDD:276965	13/47 (28%)
		KELCH repeat	500..546	CDD:276965	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810