Protein Alignment dbo and F47D12.7

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_498380.1
• Gene: F47D12.7 / 175891
• WormBaseID: WBGene00018563
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 592
• Identity: 150/592 - (25%)
• Similarity: 239/592 - (40%)
• Gaps: 112/592 - (18%)

  Fly    31 SSVGSTAVDRPPSPARLSHTSEK--HPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSAC 93
            ||:..:.|.|......|:.:.|:  .|.|||    :||.:.|:           || .|.:||..
 Worm    25 SSIEESPVKRVKFSPELTKSFEETLSPTVTL----VLRNNEEV-----------IF-DRYLLSFY 73

  Fly    94 SSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF--CYTAHI---IVEESNVQTLLPAACL-- 151
            |:||..:|:.:..:|..|...||.|..:.:..|:..  .:...|   |..:..::.|.|||.|
 Worm    74 SNYFRVLFSSKFRDSNSTTHRIRLISASDLHFLLTIPKAFEQGIKPNITLQKAIELLEPAAFLQM 138

  Fly   152 -LQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPV 215
             :.|..|.||.|:.|..:    |.:.|...|..:.....:|:.....: .||.:..:..:|.|..
 Worm   139 SIALDYISDIICKNLTHE----NIIKIFRLALLYHTTLAVRVWRSMVR-KFQTLFATNVYLSLKE 198

  Fly   216 GQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLL 280
            .:|:.::....||::||::. ..|::|:|:|...:...|.|..|
 Worm   199 NELIGLLTDKHLNLKSEDET-TVVVNWIKHNSPLQSDRLTQFAQ--------------------- 241

  Fly   281 VRSDEACRDLVDEAKNYLLLPQERPLMQGPR---TRPRKPTRRGEVLFAVGGWCSGDAIASVERF 342
                          :|:    ..||.....:   .|.|:|.   :.:...|||.|......:|..
 Worm   242 --------------RNF----SRRPQPDATKYEVIRTRQPM---DAIVCFGGWASRGVAQKIEVC 285

  Fly   343 DPQTNDWKMV-----APMSKRRCGVGVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQW------ 396
            :.:::.|:..     .| :..|...|:.|:.|.|...||.||.....:...:|..|.:|
 Worm   286 NTRSDRWQTCNFNYDIP-NIHRAYHGIEVVEDKLIVYGGFDGIKQFQTTVLFDLSTKEWRRGANM 349

  Fly   397 ---SCDVAPTTSCRTSVGVAVLDGF----LYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRR 454
               .|.|   ||.|      |.|.:    ::|.||.:||..|...|.||.:.::|::||.||..|
 Worm   350 NDKRCYV---TSAR------VNDSYGRPLVFACGGMNGVSRLKTAEMYDYRADQWTEVANMTQMR 405

  Fly   455 LGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSP-MSTRRKHLGC---AVFNNYIYA 515
            ...||..:...:.||||.||:......|.|||..:.|..:|. |.|||  .||   ::.|.....
 Worm   406 SDGAVVTIDNKIVAIGGFDGRNIHQGGEVYDPVLDLWHPLSSNMRTRR--TGCTAVSIMNQVCMI 468

  Fly   516 VGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNG-QLYAVGGFDGSAYLKTIEVYD 579
            :||.:....|.|||.|:.....|.|...:.:.||......::. .:|..|||||....|..|..|
 Worm   469 IGGFNGNRRLDSAEIYDMREGLWHPEPTLQTARSNFSACQMDTCYVYVAGGFDGQTTTKESERLD 533

  Fly   580 PETNQWR 586
            ..:..|:
 Worm   534 LRSKMWQ 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	37/136 (27%)
		PHA03098	69..587	CDD:222983	138/552 (25%)
		KELCH repeat	359..403	CDD:276965	14/52 (27%)
		KELCH repeat	407..451	CDD:276965	15/47 (32%)
		KELCH repeat	454..497	CDD:276965	15/43 (35%)
		KELCH repeat	501..545	CDD:276965	13/46 (28%)
		KELCH repeat	548..593	CDD:276965	12/40 (30%)
F47D12.7	NP_498380.1	PHA03098	44..554	CDD:222983	145/573 (25%)
		NanM	306..559	CDD:442289	76/246 (31%)
		KELCH repeat	306..349	CDD:276965	12/42 (29%)
		KELCH repeat	353..402	CDD:276965	19/57 (33%)
		KELCH repeat	405..447	CDD:276965	14/41 (34%)
		KELCH repeat	453..499	CDD:276965	13/47 (28%)
		KELCH repeat	501..545	CDD:276965	12/40 (30%)