Protein Alignment dbo and KLHL32

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_443136.2
• Gene: KLHL32 / 114792
• HGNCID: 21221
• Length: 620
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 179/564 - (31%)
• Similarity: 285/564 - (50%)
• Gaps: 40/564 - (7%)

  Fly    46 RLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQ 110
            ||.| ||.|....|..||..|....|||:.|....:|..||:.:|:|||.||.|||:..:.||..
Human    17 RLCH-SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80

  Fly   111 TEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCL 175
            .||.:..:....::..::|.||..|::|...:|.:|.|...|||:|:.::|..:|.::|:..|.|
Human    81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYL 145

  Fly   176 GIRAFADTHSCRELLRIADKFTQHNFQEVMES--EEFLLLPVGQLVDIICSDELNVRSEEQVFNA 238
            .:...||..:...|.:....|...:..|:::|  ||.|.||...|.:::.||.|...||||::..
Human   146 DLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQL 210

  Fly   239 VMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQE 303
            .:.||::|.  ..|::.::||::|..|:....|.....|..||::.|....||:||..|......
Human   211 AVRWLEHNC--HYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYA 273

  Fly   304 RPLMQGPRTRPRKPTRRGEVLFAVGG----WCSGDAIASVERFDP--QTN-------DWKMVAPM 355
            :|:.|..||:||   .:.:.|:.:||    .|.   :..:..|:|  |.|       :|..:|||
Human   274 QPVWQTRRTKPR---FQSDTLYIIGGKKREVCK---VKELRYFNPVDQENALIAAIANWSELAPM 332

  Fly   356 SKRRCGVGVAVLNDLLYAVGGH----DGQS-YLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVL 415
            ...|....|||:.|.|:..||.    .|:: .:.:..||||::|.|: ::||..:||....:..:
Human   333 PVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWA-EIAPMKNCREHFVLGAM 396

  Fly   416 DGFLYAVGGQDGV-QCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPL- 478
            :.:||||||::.: |.|..||||.||:|||:.|..........|..|..|.|:..||.......
Human   397 EEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQ 461

  Fly   479 NTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRD-----DCMELSSAERYNPLTNTW 538
            |.:..|:|..|||::.|||..||.:...|.....:|.:||.|     |.:.:...:.||..|:.|
Human   462 NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQW 526

  Fly   539 SPI-VAMTSRRSGVGLAVVNGQLYAVGGFD--GSAYLKTIEVYD 579
            :.. ..:.:.::..|:||.||::|.|||:.  .:..|..|:|.|
Human   527 TRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLD 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	44/126 (35%)
		PHA03098	69..587	CDD:222983	169/541 (31%)
		KELCH repeat	359..403	CDD:276965	16/48 (33%)
		KELCH repeat	407..451	CDD:276965	19/44 (43%)
		KELCH repeat	454..497	CDD:276965	13/43 (30%)
		KELCH repeat	501..545	CDD:276965	11/49 (22%)
		KELCH repeat	548..593	CDD:276965	13/34 (38%)
KLHL32	NP_443136.2	BTB_POZ_KLHL32	14..146	CDD:349570	46/129 (36%)
		BACK_KLHL32_BKLHD5	139..236	CDD:350546	29/98 (30%)
		Kelch 1	290..346		16/58 (28%)
		Kelch	291..346	CDD:128874	16/57 (28%)
		NanM	324..595	CDD:442289	81/248 (33%)
		KELCH repeat	336..384	CDD:276965	16/48 (33%)
		Kelch 2	347..398		14/51 (27%)
		KELCH repeat	388..433	CDD:276965	19/44 (43%)
		Kelch 3	399..446		20/46 (43%)
		KELCH repeat	436..482	CDD:276965	15/45 (33%)
		Kelch 4	447..494		15/46 (33%)
		KELCH repeat	484..534	CDD:276965	11/49 (22%)
		Kelch 5	496..547		12/50 (24%)
		Kelch 6	549..599		8/22 (36%)