Protein Alignment dbo and IVNS1ABP

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_006460.2
• Gene: IVNS1ABP / 10625
• HGNCID: 16951
• Length: 642
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 192/633 - (30%)
• Similarity: 302/633 - (47%)
• Gaps: 100/633 - (15%)

  Fly    47 LSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQT 111
            |....|...:.::.:||.||:..:.|||.|.|.|.::.|||.:|:.||.|...:|..:.:....:
Human     7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGIS 71

  Fly   112 EVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLG 176
            .|...|::..|:|:|:::.|||.:..::..|:.:..||..|::..::.:|.::|..::|.|:|:.
Human    72 HVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136

  Fly   177 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMS 241
            .|.||.......||...|.:.|.:..::.|.||||.||..:| :::..|.:.:.|..:::..|::
Human   137 YRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200

  Fly   242 WLKYNVAERRQHLAQVLQHVRL-------PLLSPKFLVG---TVGSD------------------ 278
            |::.::.|....|.::::.|:.       .||....|.|   ..|||
Human   201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHK 265

  Fly   279 LLVRSDEACRD--------------LVDEAK----NYLLL-----------------PQERP--- 305
            .:..|...|..              :|...|    .||.|                 ||..|
Human   266 QISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTST 330

  Fly   306 ---------------LMQGPRTRPRKPTRRG----EV---LFAVGGWCSGDAIASVERFDPQTND 348
                           |::.|.: |.:..|.|    |:   |.|.||:...:.:.:||.::|.|:.
Human   331 PKLSKSLSFEMQQDELIEKPMS-PMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH 394

  Fly   349 WKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQS-YLNSIERYDPQTNQWSCDVAPTTSCRT---S 409
            |..:|||...|....:|||...||.|||.:|.| .|:..|.||...:.|    .|....||   :
Human   395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDW----IPVPELRTNRCN 455

  Fly   410 VGVAVLDGFLYAVGGQD--GVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGS 472
            .||..|:|.||.|||.|  |.:.|.:.:.:||....|:..||:..||...||..|||:||.|||:
Human   456 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520

  Fly   473 DGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNT 537
            :....|||||||:|.:|.|..::||:..|:..|.||.|..::..||.|....:|..|.|:|..|.
Human   521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNE 585

  Fly   538 WSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQW 585
            |..:..|||.||..|:|.|...:||||||||:.:|.|:|||:.|:|:|
Human   586 WKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	36/126 (29%)
		PHA03098	69..587	CDD:222983	186/611 (30%)
		KELCH repeat	359..403	CDD:276965	16/44 (36%)
		KELCH repeat	407..451	CDD:276965	19/48 (40%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	14/43 (33%)
		KELCH repeat	548..593	CDD:276965	21/38 (55%)
IVNS1ABP	NP_006460.2	BTB_POZ_NS1BP	14..137	CDD:349615	35/122 (29%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	25/96 (26%)
		Sufficient for AHR interaction and signaling	164..368		38/205 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..281		2/23 (9%)
		NanM	349..627	CDD:442289	111/282 (39%)
		KELCH repeat	358..401	CDD:276965	13/42 (31%)
		Kelch 1. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	384..421		14/36 (39%)
		KELCH repeat	409..451	CDD:276965	16/45 (36%)
		Kelch 2. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	432..469		13/40 (33%)
		KELCH repeat	453..498	CDD:276965	16/44 (36%)
		Kelch 3. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	481..518		14/36 (39%)
		KELCH repeat	502..545	CDD:276965	21/42 (50%)
		Kelch 4. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	527..565		16/37 (43%)
		KELCH repeat	549..593	CDD:276965	14/43 (33%)
		Kelch 5. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	575..612		15/36 (42%)
		KELCH repeat	596..635	CDD:276965	21/38 (55%)
		Kelch 6. /evidence=ECO:0000303|PubMed:30538201, ECO:0007744|PDB:6N3H	622..642		7/12 (58%)