Protein Alignment dbo and klhl21

DIOPT Version :10

• Sequence 1: NP_524989.2
• Gene: dbo / 53556
• FlyBaseID: FBgn0040230
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_002933898.2
• Gene: klhl21 / 100495738
• XenbaseID: XB-GENE-5802687
• Length: 615
• Species: Xenopus tropicalis
• Alignment Length: 592
• Identity: 185/592 - (31%)
• Similarity: 277/592 - (46%)
• Gaps: 52/592 - (8%)

  Fly    41 PPSPARLSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGEL 105
            |.|.|.|......|....|..:|.||..::..|:.::.||:....||.:|:|.|:||.|||.|.|
 Frog    15 PASEASLPFYDASHALHLLRGINELRAEQKFFDMTVSAGGQDFPCHRTVLAAASNYFRAMFAGRL 79

  Fly   106 EESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLD 170
            .||....|.:.|:....:.||:|||||..:.|...||:.||.||.|.|...:::.||.:|::|||
 Frog    80 RESHVDRVELHDVTGPILSLLLDFCYTGRVTVTLENVEPLLQAADLFQFPSVKEACCAYLEQQLD 144

  Fly   171 PTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQV 235
            .:|||.|:.||:.::|:.|.....:|...:..::.::.|...|...::::.|..|.|.|..||..
 Frog   145 VSNCLEIQDFAEAYACQGLAESTKRFILAHMAQLAQAHEVERLTFKRMLEYISDDRLCVDKEEAA 209

  Fly   236 FNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLL 300
            |...:.|:|.:...|:....::.|::|||.:...:|:..|.||.||.....|..|:.||:.:...
 Frog   210 FQIALQWVKADPKHRQYRWPELFQYLRLPFIRRFYLLAYVESDPLVYRSPYCLQLIREARAFQSS 274

  Fly   301 PQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDA--IASVERFDPQTNDWKMVAPMSKR-RCGV 362
            ..:|......|.:||..|...|:|..||| |..|.  :.:|:.::.||..|:.:|..... ..|.
 Frog   275 EYDRHDWPCHRMKPRPSTGLAEILVVVGG-CDQDCDELVTVDCYNAQTGQWRYLAEFPDHLGGGY 338

  Fly   363 GVAVLNDLLYAVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDG 427
            .:..|.:.:|..||.||....:.:.||:...|:|: :|:|....|......||:|.||.:..
 Frog   339 SITALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWT-EVSPMLKAREYHSSTVLNGLLYVIAS--- 399

  Fly   428 VQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDG------QCPLNTVERYDP 486
                :..|||||..:.|..:.||.......:.......|||||..:|      ||       |:|
 Frog   400 ----DSTERYDPTMDTWESLRPMLYPMDNCSTTSCRKKLYAIGSLEGKESMVMQC-------YNP 453

  Fly   487 RHNKWVAVS-----PMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTS 546
            ..|.|..|:     |.|...|   ....|..||.|  |||..|:   :.|:|..|.|..|..|..
 Frog   454 DTNLWSMVNCGQLPPWSFAPK---TVTLNGLIYFV--RDDSAEV---DVYSPSKNEWDKIPPMIQ 510

  Fly   547 RRSGVGLAVVNGQLYAVGGFDGSAYLK-TIEVYDPETNQWRLCGCMNYRRL------GGGVGVMR 604
            ...|..||.:.|:||..||:|.:..|. .:|.:||||..|.|.|     ||      .|.|.:.|
 Frog   511 VHVGGSLAALGGKLYVSGGYDNTFELSDVVEAFDPETRLWSLVG-----RLPQPTFWHGSVSIFR 570

  Fly   605 --APQTE 609
              .|||:
 Frog   571 QFMPQTQ 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	48/126 (38%)
		PHA03098	69..587	CDD:222983	166/532 (31%)
		KELCH repeat	359..403	CDD:276965	12/43 (28%)
		KELCH repeat	407..451	CDD:276965	13/43 (30%)
		KELCH repeat	454..497	CDD:276965	13/53 (25%)
		KELCH repeat	501..545	CDD:276965	14/43 (33%)
		KELCH repeat	548..593	CDD:276965	18/45 (40%)
klhl21	XP_002933898.2	BTB_POZ_KLHL21	25..148	CDD:349559	46/122 (38%)
		PHA03098	43..557	CDD:222983	169/542 (31%)
		BACK_KLHL21	143..243	CDD:350535	27/99 (27%)
		KELCH repeat	336..378	CDD:276965	12/42 (29%)
		KELCH repeat	382..419	CDD:276965	13/43 (30%)
		KELCH repeat	422..461	CDD:276965	12/45 (27%)
		KELCH repeat	512..558	CDD:276965	20/50 (40%)