DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dbo and LOC100489128

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_012809305.2	Gene:	LOC100489128 / 100489128	-ID:	-	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	581	Identity:	209/581 - (35%)
Similarity:	314/581 - (54%)	Gaps:	21/581 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TAVDRPPSPAR--LSHTSEKHPKVTLTELNMLRRHRELCDVVLNV--GGRK--IFAHRVILSACS 94
            ||:..|.....  |.:|.|.|......:::.:||:..||||:|.|  .|::  ...|:::|::||
Frog    29 TAIAVPSMKGHGYLDYTIENHTSKAFEKMDEMRRNNLLCDVLLRVSYNGKEEDFHVHKIVLASCS 93

  Fly    95 SYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQD 159
            .:|.||||....|....||||:||....|:.||:|.||:.|.|.|..|..:|.||...|:.::..
Frog    94 PFFRAMFTNNFRECHAREVTIKDICPKVMQRLIEFAYTSRITVGEKCVLHVLLAAMRYQMEDVAK 158

  Fly   160 ICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICS 224
            .|.:||.:.||.:|.:||..||:...|.||.|...::...:|.||...||||.|...:|:|::..
Frog   159 ACSDFLVKHLDASNVIGISNFAEQIGCHELYRTGREYINTHFSEVTNEEEFLSLSHCELLDLVSQ 223

  Fly   225 DELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRD 289
            |.|||..|.:|:||.:.|:::::..|.|:...:|..|.|..|..|||...:....::..:..||.
Frog   224 DSLNVLCESEVYNACLKWMQWDLNNRAQYFHALLNAVHLYSLPAKFLEIQLKKCPILSKENRCRV 288

  Fly   290 LVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSGDAIASVERFDPQTNDWKMVAP 354
            .:.:....:.|  .:||       ||...|..::::..||:.. ::::|::.|:|||.:|..:|.
Frog   289 YLSKIFQEMCL--HKPL-------PRPKQRGNQLIYVAGGYLQ-NSLSSMDAFNPQTGEWIKLAD 343

  Fly   355 MSKRRCGVGVAVLNDLLYAVGGHDGQSYLNS----IERYDPQTNQWSCDVAPTTSCRTSVGVAVL 415
            |.:.|.|:|..:::.|.|||||.:.....|:    :..::|.||||: ..||....|..||||.:
Frog   344 MLEPRSGLGACIVSGLFYAVGGRNNSCQENTDSDLLSFFNPVTNQWA-SRAPMNVPRNRVGVAEI 407

  Fly   416 DGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNT 480
            ||.:||.||..|.:....||:|||..::|:.||||.|.|:|..|....|.||.:||.||....||
Frog   408 DGAIYAAGGSCGSEHHKSVEKYDPDNDRWTFVAPMPTARIGAGVVACRGRLYVVGGFDGDTRWNT 472

  Fly   481 VERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMT 545
            |:.|||..::|..|:.|.|.|...|....:||:|||||.|...:|.|.||||...|.|..:..|.
Frog   473 VDCYDPEEDQWQPVASMETIRSGAGVVALDNYLYAVGGYDGTNQLDSVERYNIERNYWEAMAPMK 537

  Fly   546 SRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMRAP 606
            .|||..||.|..|::||:|||:...:|.::|.|.|:.|:|.....|.....|.||.|...|
Frog   538 HRRSAHGLTVHQGKIYALGGFNAGGFLSSVECYCPDRNEWTEVTVMPTGCSGMGVAVTMEP 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	48/130 (37%)
		PHA03098	69..587	CDD:222983	194/525 (37%)
		KELCH repeat	359..403	CDD:276965	16/47 (34%)
		KELCH repeat	407..451	CDD:276965	21/43 (49%)
		KELCH repeat	454..497	CDD:276965	18/42 (43%)
		KELCH repeat	501..545	CDD:276965	18/43 (42%)
		KELCH repeat	548..593	CDD:276965	18/44 (41%)
LOC100489128	XP_012809305.2	BTB_POZ_KLHL19_KEAP1	46..169	CDD:349557	44/122 (36%)
		PHA03098	67..585	CDD:222983	194/528 (37%)
		KELCH repeat	348..395	CDD:276965	16/47 (34%)
		KELCH repeat	399..442	CDD:276965	20/42 (48%)
		KELCH repeat	446..489	CDD:276965	18/42 (43%)
		KELCH repeat	493..537	CDD:276965	18/43 (42%)
		KELCH repeat	540..585	CDD:276965	18/44 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010