DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and klhl28

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_017207216.1	Gene:	klhl28 / 100333404	-ID:	-	Length:	571	Species:	Danio rerio

Alignment Length:	557	Identity:	249/557 - (44%)
Similarity:	338/557 - (60%)	Gaps:	15/557 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HPKVTLTELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDI 118
            |.:..|..|.:||:..||||:||.||..||.||:|:|::.|.||.|||||.|.|...:||..:.|
Zfish    17 HSEQLLQGLQLLRQDHELCDIVLRVGDAKIHAHKVVLASISPYFKAMFTGNLSEKETSEVEFQCI 81

  Fly   119 DENAMELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADT 183
            ||.|::.::::.||..:.:.:..|::|||||.|||:..:...||.||:.|||..||:||..||:|
Zfish    82 DEAALKAIVEYAYTGTVFISQETVESLLPAANLLQVKLVLKECCSFLESQLDAGNCIGISRFAET 146

  Fly   184 HSCRELLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVA 248
            :.|.:|...|.||...:|:||.::|||..|...:|.||:.:|.|||.:||.||.|:.||:||:|:
Zfish   147 YGCHDLCLAASKFICQHFEEVCQTEEFFELTRAELDDIVSNDCLNVLTEESVFYALESWIKYDVS 211

  Fly   249 ERRQHLAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGP-RT 312
            ||:|||||:|..|||||||.|||.....::.|:|.|.||:.|::||..|..:|:.|...|.. .|
Zfish   212 ERQQHLAQLLHCVRLPLLSVKFLTRLYEANHLIRDDHACKHLLNEALKYHFMPEHRLSYQTVLST 276

  Fly   313 RPRKPTRRGEVLFAVGGWCSGDA-IASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGG 376
            |||...:   ||.||||.....| :.|:|.:.|||:.|..:||:...|...|||||...:|.:||
Zfish   277 RPRCAPK---VLLAVGGKAGLFATLESMEMYFPQTDSWLGLAPLPVPRYEFGVAVLEQQVYVLGG 338

  Fly   377 -----HDGQSYL---NSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNH 433
                 ..|.||.   :|:||:.|.||.||.:.....| |:::||.||.|.|||:||.||...|..
Zfish   339 IATHMRQGISYRRHESSVERWHPDTNTWSSERRMAES-RSTLGVVVLAGELYALGGYDGQYYLQS 402

  Fly   434 VERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMS 498
            ||:|.||..:|..|||||..|...|.|||.|.:|||||. |...:|:||||||..:.|..|:||:
Zfish   403 VEKYLPKLKEWQPVAPMTKSRSCFATAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWDMVAPMA 466

  Fly   499 TRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAV 563
            .:|.:.|..|...:|:.|||.:....|||.|||:|..|.|:....|...|:|||.|||:..||.|
Zfish   467 DKRINFGVGVMLGFIFVVGGHNGVSHLSSIERYDPYQNQWTACRPMNEPRTGVGSAVVDNLLYVV 531

  Fly   564 GGFDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGV 600
            ||..||:||..::.|||.|:.|.....|.|.|...|:
Zfish   532 GGHSGSSYLNAVQRYDPLTDGWIDASGMMYCRCNFGL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	55/121 (45%)
		PHA03098	69..587	CDD:222983	240/527 (46%)
		KELCH repeat	359..403	CDD:276965	20/51 (39%)
		KELCH repeat	407..451	CDD:276965	23/43 (53%)
		KELCH repeat	454..497	CDD:276965	21/42 (50%)
		KELCH repeat	501..545	CDD:276965	16/43 (37%)
		KELCH repeat	548..593	CDD:276965	22/44 (50%)
klhl28	XP_017207216.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59391
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930