DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and klhl18

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001123404.1	Gene:	klhl18 / 100170176	XenbaseID:	XB-GENE-5759414	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	240/544 - (44%)
Similarity:	335/544 - (61%)	Gaps:	9/544 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDF 129
            :||..:||||.|.||..|..|||::|:|...||.||||.::.|.:|.|:.::.:|.:|:|.||:|
Frog    30 IRRQGKLCDVTLRVGEHKFSAHRIVLAASIPYFHAMFTNDMVECKQDEIVMQGMDASALEALINF 94

  Fly   130 CYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIAD 194
            .|..|:.:::.|||:||..|..|||..|:|.||.|||.:|.|.||||:|.||:|..|..|...::
Frog    95 AYNGHLAIDQQNVQSLLMGASFLQLQNIKDACCTFLKERLHPKNCLGVRQFAETMMCAVLHDASN 159

  Fly   195 KFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQ 259
            :|...:|.||..|||||.|...::::::..|||||::|||||.|.::|::|:..:|...|.::|.
Frog   160 RFIHEHFVEVSMSEEFLALAFEEVLELVSRDELNVKAEEQVFEAALAWVRYDREKREVFLPELLS 224

  Fly   260 HVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPTRRGEVL 324
            .:||||..|:||...|..|.|||....|||||||||:|.|:|:.||.:...:||||..|....::
Frog   225 KIRLPLCRPQFLTDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLLAFKTRPRCCTSIAGLI 289

  Fly   325 FAVGG------WCSGDAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHDGQSYL 383
            :||||      :.:||::..||.|||..|.|:...||:..|..|||||:|.||||:||:||||.|
Frog   290 YAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCQPMTTARSRVGVAVVNGLLYAIGGYDGQSRL 354

  Fly   384 NSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVA 448
            :::|.|:|.|:.|: .|....|.|:::|..||||.:|..||.||...||.||.|.|:.:||:.|.
Frog   355 STVEVYNPDTDTWT-KVGSMNSKRSAMGTVVLDGQIYVCGGYDGNCSLNSVEAYSPETDKWTVVT 418

  Fly   449 PMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYI 513
            ||::.|....|.|..|.:|..||.||....||||.|:.....|..|:.|..:|...|.|...:.:
Frog   419 PMSSNRSAAGVTVFEGRIYVSGGHDGLQIFNTVEYYNHHTATWHPVASMMNKRCRHGAASLGSKM 483

  Fly   514 YAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVY 578
            |..||.:....||.||.||.:.:.|..|..|.:|||.|.|....|:||||||:||.:.|.::|:|
Frog   484 YICGGYEGSAFLSVAEVYNSMADQWYLITPMNTRRSRVSLVANCGRLYAVGGYDGQSNLNSVEMY 548

  Fly   579 DPETNQWRLCGCMNYRRLGGGVGV 602
            |||||:|.....|....  |||||
Frog   549 DPETNRWTFMAPMVCHE--GGVGV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	52/110 (47%)
		PHA03098	69..587	CDD:222983	232/523 (44%)
		KELCH repeat	359..403	CDD:276965	24/43 (56%)
		KELCH repeat	407..451	CDD:276965	21/43 (49%)
		KELCH repeat	454..497	CDD:276965	16/42 (38%)
		KELCH repeat	501..545	CDD:276965	14/43 (33%)
		KELCH repeat	548..593	CDD:276965	23/44 (52%)
klhl18	NP_001123404.1	BTB_POZ_KLHL18	18..133	CDD:349556	48/102 (47%)
		PHA03098	33..556	CDD:222983	231/523 (44%)
		BACK_KLHL18	134..240	CDD:350532	45/105 (43%)
		KELCH repeat	281..326	CDD:276965	14/44 (32%)
		KELCH repeat	330..373	CDD:276965	24/43 (56%)
		KELCH repeat	377..421	CDD:276965	21/43 (49%)
		KELCH repeat	424..468	CDD:276965	16/43 (37%)
		KELCH repeat	471..515	CDD:276965	14/43 (33%)
		KELCH repeat	518..561	CDD:276965	22/42 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010