DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and klhl41a

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_001922967.1	Gene:	klhl41a / 100148315	ZFINID:	ZDB-GENE-081105-22	Length:	599	Species:	Danio rerio

Alignment Length:	580	Identity:	155/580 - (26%)
Similarity:	259/580 - (44%)	Gaps:	59/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMF---TGELEESRQTEVTIRDIDENAM 123
            |..|.:..:..|.:|.||.|.:..||:|::|||.||..::   .|..::....||.:.::|.|.|
Zfish    22 LKELLKENKFVDCILKVGDRSLPCHRLIMAACSPYFRELYFTEDGTEKKDANKEVVLENVDPNIM 86

  Fly   124 ELLIDFCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRE 188
            ::::::.|:|.|.:.:.|||.:...|...|:..:..:|..:|:.:|...|||.|.......:|..
Zfish    87 DMIVNYLYSADIDITDDNVQDVFAVANKFQIPSVFTVCVNYLQNKLSLGNCLAIFRMGLVLNCPR 151

  Fly   189 LLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQH 253
            |...|..|...:|:.:.:.||||.....:...||..|.|||..||.||..:|.|::.|...|.:.
Zfish   152 LAVSARDFIAEHFETLSKDEEFLEFNAPEFFAIIGCDALNVEKEELVFELLMKWVRKNKENRAKA 216

  Fly   254 LAQVLQHVRLPLLSPKFLVGTVGSDLLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRKPT 318
            |....:|:|..||..|:|...|..|.::::|.   :|:.:.|..      :....|...:.::..
Zfish   217 LGDAFEHIRFRLLPEKYLKEKVEKDDIIKADP---ELIKKLKVI------KDAFAGKLPQIKEGE 272

  Fly   319 RRGEVLFAVGGWCSG---------DAIASVE-----RFDPQTNDWKMVAPMSKR--RCGVGVAVL 367
            :.||....:.|:.:.         |.|..:.     .:|...|:. .:|.|:::  |..|.:...
Zfish   273 KEGEGENELPGFLNDSQRLGMFNRDLILMINDTAAVAYDANENEC-FLAAMAEQIPRNHVSITSK 336

  Fly   368 NDLLYAVGG--HDGQSYLNSIERY----DPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQD 426
            .:|||..||  .|.::..:.::.|    ||.:..|.. :.|..|.|....:...:..|:||.|:|
Zfish   337 KNLLYVAGGLFVDEENKDSPLQCYFYQMDPHSPNWIA-LPPMPSPRCLFAMGEFENLLFAVAGKD 400

  Fly   427 --GVQCLNHVERYDPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGG-SDGQCPLNTVERYDPRH 488
              ..:.|:.|..||..:.||.:...:..|..|.:|....|.:|.||| :|....:|.:..|:.:.
Zfish   401 LQSNESLDSVLCYDVDKMKWLETKKLPLRIHGHSVISQNGLVYCIGGKTDENKTINKMFAYNHKK 465

  Fly   489 NKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCMELSSAERYNPLTNTWSPIVAMTSRRSGVGL 553
            ::|..::.|.|.|...|..|....|..|||.::...|||.|.|:..||.|.........||.|.:
Zfish   466 SEWKELAAMKTPRSMFGATVHKGKIVVVGGVNEDGLLSSCEAYDFGTNKWEVFAEFAQERSSVNV 530

  Fly   554 AVVNGQLYAVGGFD---------GSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMR 604
            ..|:|.||||.||.         ..:.:..|..|:.:..||           .|.:|.||
Zfish   531 LSVDGVLYAVAGFTIKENEDKQCVPSEITDIWQYEEDKKQW-----------SGMIGEMR 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	34/116 (29%)
		PHA03098	69..587	CDD:222983	149/554 (27%)
		KELCH repeat	359..403	CDD:276965	12/49 (24%)
		KELCH repeat	407..451	CDD:276965	12/45 (27%)
		KELCH repeat	454..497	CDD:276965	11/43 (26%)
		KELCH repeat	501..545	CDD:276965	15/43 (35%)
		KELCH repeat	548..593	CDD:276965	15/53 (28%)
klhl41a	XP_001922967.1	BTB	22..129	CDD:279045	30/106 (28%)
		PHA03098	46..521	CDD:222983	129/485 (27%)
		BACK	137..239	CDD:285009	33/101 (33%)
		KELCH repeat	328..377	CDD:276965	12/49 (24%)
		Kelch	339..391	CDD:128874	13/52 (25%)
		Kelch_1	380..420	CDD:279660	10/39 (26%)
		Kelch_6	431..478	CDD:290672	13/46 (28%)
		KELCH repeat	431..474	CDD:276965	11/42 (26%)
		Kelch_1	477..520	CDD:279660	15/42 (36%)
		KELCH repeat	478..522	CDD:276965	15/43 (35%)
		KELCH repeat	525..578	CDD:276965	17/63 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810