DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dbo and keap1b

DIOPT Version :9

Sequence 1:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001106948.1	Gene:	keap1b / 100003679	ZFINID:	ZDB-GENE-080508-1	Length:	593	Species:	Danio rerio

Alignment Length:	612	Identity:	219/612 - (35%)
Similarity:	328/612 - (53%)	Gaps:	49/612 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSVGSTAVDRPPSPAR------LSHTSEKHPKVTLTELNMLRRHRELCDVVLNVGGRKI------ 83
            ::.|.|......:|:.      .|:|.|.|.......:|.|||.|:||||.|.|....:
Zfish     3 AAAGMTECKAEVTPSASNGHRVFSYTLESHTAAAFAIMNELRRERQLCDVTLRVRYCPLDTHVDF 67

  Fly    84 FAHRVILSACSSYFCAMFTGELEESRQTEVTIRDIDENAMELLIDFCYTAHIIVEESNVQTLLPA 148
            .||:|:|::.|..|.||||..|:|.....|.|..|....|..||:|.|||.|.|.|..|..::..
Zfish    68 VAHKVVLASSSPVFRAMFTNGLKECGMEVVPIEGIHPKVMGRLIEFAYTASISVGEKCVIHVMNG 132

  Fly   149 ACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFLLL 213
            |.:.|:..:...||:||..||||:|.:||.:||:...|.||.:.|.::...||.:|...|||..|
Zfish   133 AVMYQIDSVVQACCDFLVEQLDPSNAIGIASFAEQIGCTELHQKAREYIYMNFSQVATQEEFFTL 197

  Fly   214 PVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVLQHVRLPLLSPKFLVGTVGSD 278
            ...|||.:|..||||||.|.:||:|.::|::|:..|||.::..:||.||...|:|.||.
Zfish   198 SHCQLVTLISRDELNVRCESEVFHACVAWVQYDREERRPYVQALLQAVRCHSLTPHFLQ------ 256

  Fly   279 LLVRSDEACRDLVD-----EAKNYLL-----LPQERPLMQGPRTRPRKPTRRGEVLFAVGGWCSG 333
                     |.|..     ::|:||.     |...:|....|...|:.|    ::::.|||:..
Zfish   257 ---------RQLEHFEWDAQSKDYLSQIFRDLTLHKPTKVIPLRTPKVP----QLIYTVGGYFR- 307

  Fly   334 DAIASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLYAVGGH----DGQSYLNSIERYDPQTN 394
            .:::.:|.|:|.:..|..:|.:...|.|:...|::.|||||||.    ||....::::.|:|..|
Zfish   308 QSLSFLEAFNPCSGAWLRLADLQVPRSGLAACVISGLLYAVGGRNNGPDGNMDSHTLDCYNPMNN 372

  Fly   395 QW-SCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERYDPKENKWSKVAPMTTRRLGVA 458
            .| .|  |..:..|..:||.|:||.:|||||..|....|.||||||:.:.|..|:||.|||:||.
Zfish   373 CWRPC--AHMSVPRNRIGVGVIDGMIYAVGGSHGCTHHNSVERYDPERDSWQLVSPMLTRRIGVG 435

  Fly   459 VAVLGGFLYAIGGSDGQCPLNTVERYDPRHNKWVAVSPMSTRRKHLGCAVFNNYIYAVGGRDDCM 523
            |||:...|||:||.||...|::.|.|:|..::|.:::.|:|.|...|.....||||.:||.|...
Zfish   436 VAVINRLLYAVGGFDGTHRLSSAECYNPERDEWRSIAAMNTVRSGAGVCALGNYIYVMGGYDGTN 500

  Fly   524 ELSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLYAVGGFDGSAYLKTIEVYDPETNQWRLC 588
            :|::.|||:...::||...:|..|||.:|:...:|::|.:||:||:.:|.::|.:||||:.|...
Zfish   501 QLNTVERYDVEKDSWSFSASMRHRRSALGVTTHHGRIYVLGGYDGNTFLDSVECFDPETDSWTEV 565

  Fly   589 GCMNYRRLGGGVGVMRAPQTENYMWCE 615
            ..|...|.|.||.|...|..:..:.|:
Zfish   566 THMKSGRSGVGVAVTMEPCHKELIPCQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	51/132 (39%)
		PHA03098	69..587	CDD:222983	200/538 (37%)
		KELCH repeat	359..403	CDD:276965	18/48 (38%)
		KELCH repeat	407..451	CDD:276965	22/43 (51%)
		KELCH repeat	454..497	CDD:276965	18/42 (43%)
		KELCH repeat	501..545	CDD:276965	15/43 (35%)
		KELCH repeat	548..593	CDD:276965	17/44 (39%)
keap1b	NP_001106948.1	BTB_POZ_KLHL19_KEAP1	29..154	CDD:349557	46/124 (37%)
		PHA03098	69..563	CDD:222983	192/515 (37%)
		BACK_KLHL19_KEAP1	152..242	CDD:350533	39/89 (44%)
		KELCH repeat	333..380	CDD:276965	18/48 (38%)
		KELCH repeat	384..427	CDD:276965	21/42 (50%)
		KELCH repeat	431..474	CDD:276965	18/42 (43%)
		KELCH repeat	478..522	CDD:276965	15/43 (35%)
		KELCH repeat	525..570	CDD:276965	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820