DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krz and SAG

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_000532.2	Gene:	SAG / 6295	HGNCID:	10521	Length:	405	Species:	Homo sapiens

Alignment Length:	424	Identity:	193/424 - (45%)
Similarity:	262/424 - (61%)	Gaps:	55/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDVLG 113
            :|||.|.:..:|:|||.||::|||:.|.|:||||.:||:.||.:||:..:..|||||:||:||:|
Human    16 IFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVKGKKVYVTLTCAFRYGQEDIDVIG 80

  Fly   114 LTFRKDLYLAHEQIYPPMQLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGDVGK 178
            ||||:|||.:..|:|||:......|:|||.|:||||.|.:||....|.|.|.||.|||||.|.||
Human    81 LTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTYPFLLTFPDYLPCSVMLQPAPQDSGK 145

  Fly   179 SCGVDYELKAFVGENV---EDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLE 240
            |||||:|:|||..::.   |||..|::||||.||||.:||.::|.||..|.:.:|.|....:||.
Human   146 SCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRKVQHAPLEMGPQPRAEAAWQFFMSDKPLHLA 210

  Fly   241 ATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVA 305
            .:|:||:|.|||.|.|.|.|.||:.:||||||..|.|.|::.|:|:..|...||..|:::  :|.
Human   211 VSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVVLYSSDYYVKPVAMEEAQE--KVP 273

  Fly   306 PGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLL 370
            |..||:|...|.||||||:::.|:||||::|||||||||||:|.....|..|||:|.|::||||.
Human   274 PNSTLTKTLTLLPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIKVKLT 338

  Fly   371 IS---SPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESATGGQ 432
            :|   ..|.:.::..|:||.||||:||                           |...||
Human   339 VSGFLGELTSSEVATEVPFRLMHPQPE---------------------------DPAKES----- 371

  Fly   433 DVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGA 466
                           .||.:::||:|||..||.|
Human   372 ---------------YQDANLVFEEFARHNLKDA 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	88/157 (56%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	78/162 (48%)
SAG	NP_000532.2	Arrestin_N	26..184	CDD:278754	88/157 (56%)
SAG	NP_000532.2	Arrestin_C	203..364	CDD:214976	78/162 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159518
Domainoid	1	1.000	203	1.000	Domainoid score	I2963
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.820