DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and arrb1

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001153294.1	Gene:	arrb1 / 553266	ZFINID:	ZDB-GENE-060824-1	Length:	418	Species:	Danio rerio

Alignment Length:	431	Identity:	260/431 - (60%)
Similarity:	313/431 - (72%)	Gaps:	38/431 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDL 109
            :.||||||:|.|||:|||||||||||||..|:|:||||.|||||:|:||||..:..|||||||||
Zfish     4 KGTRVFKKASPNGKLTVYLGKRDFVDHVDLVEPVDGVVLIDPEYLKERKVFVTLTCAFRYGREDL 68

  Fly   110 DVLGLTFRKDLYLAHEQIYPPM-QLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAP 173
            |||||||||||::|:.|.:||: :..:.:||||||||||||.:|:||.||:||..|.||:|||.|
Zfish    69 DVLGLTFRKDLFVANIQAFPPVPEEKKSLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGP 133

  Fly   174 GDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIH 238
            .|.||:||||:|:|||..||||:|.||||||||.||||.|||.|.|.||..|.:::|:|....:|
Zfish   134 EDTGKACGVDFEVKAFCAENVEEKIHKRNSVRLVIRKVQYAPEKPGPQPMAETTRQFLMSDKPLH 198

  Fly   239 LEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQ 303
            |||:||||:|:|||.|||||||.||:|:||||||:.|||:||||||:|||||..||..||:|  .
Zfish   199 LEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAIEESDD--I 261

  Fly   304 VAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVK 368
            |||..|..||:.|.|.||||::|.||||||:|||||||||||||:...|.:|.|||:|.||||||
Zfish   262 VAPSATFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANKEILGIIVSYKVKVK 326

  Fly   369 LLISSPLLNGDLVA-----ELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESA 428
            |::|...|.|||.:     |||||||||||.||.   :...:|.
Zfish   327 LVVSRGGLLGDLASSDVAVELPFTLMHPKPLEES---IYRDAPE--------------------- 367

  Fly   429 TGGQDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAETE 469
               .|.|..||||:.|   ..|||||||||||.||.||:.:
Zfish   368 ---NDAPIDTNLIEFD---TNDDDIIFEDFARQRLIGAKDD 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	107/155 (69%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	106/164 (65%)
arrb1	NP_001153294.1	Arrestin_N	18..174	CDD:278754	107/155 (69%)
arrb1	NP_001153294.1	Arrestin_C	193..356	CDD:214976	106/164 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595704
Domainoid	1	1.000	223	1.000	Domainoid score	I2502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2981
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1381
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm25609
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2409
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940