DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and ARRB1

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_016873239.1	Gene:	ARRB1 / 408	HGNCID:	711	Length:	473	Species:	Homo sapiens

Alignment Length:	450	Identity:	258/450 - (57%)
Similarity:	319/450 - (70%)	Gaps:	56/450 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDV 111
            :|||||:|.|||:||||||||||||:..|||:||||.:||||:|:|:|:..:..|||||||||||
Human    37 SRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDV 101

  Fly   112 LGLTFRKDLYLAHEQIYPPMQLD-RPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGD 175
            |||||||||::|:.|.:||...| :|:||||||||||||.:|:||.||:||..|.||:|||.|.|
Human   102 LGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPED 166

  Fly   176 VGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLE 240
            .||:||||||:|||..||:|:|.||||||||.||||.|||.:.|.||:.|.:::|:|....:|||
Human   167 TGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLE 231

  Fly   241 ATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVA 305
            |:||||:|:|||.|||||||.||:|:||||||:.|||:||||||:|||||..||..|::|  .||
Human   232 ASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADD--TVA 294

  Fly   306 PGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLL 370
            |..|..||:.|.|.||||::|.||||||:|||||||||||||:...|.||.|||:|.|||||||:
Human   295 PSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLV 359

  Fly   371 ISSPLLNGDLVA-----ELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESATG 430
            :|...|.|||.:     |||||||||||:||.                  |...:.:.||
Human   360 VSRGGLLGDLASSDVAVELPFTLMHPKPKEEP------------------PHREVPENET----- 401

  Fly   431 GQDVPTTTNLIQLDDDE---------------------AQDDDIIFEDFARLRLKGAETE 469
                |..||||:||.::                     :.||||:||||||.||||.:.:
Human   402 ----PVDTNLIELDTNQRPSSHRTVARGGGPGPTARTASSDDDIVFEDFARQRLKGMKDD 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	106/155 (68%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	106/164 (65%)
ARRB1	XP_016873239.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159516
Domainoid	1	1.000	226	1.000	Domainoid score	I2520
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2981
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1402
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm40898
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2409
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800