DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and ARR3

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_016885007.1	Gene:	ARR3 / 407	HGNCID:	710	Length:	403	Species:	Homo sapiens

Alignment Length:	444	Identity:	189/444 - (42%)
Similarity:	259/444 - (58%)	Gaps:	79/444 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TRVFKKSSSNGKITVYLGKRDFVDHVTHVDPI---------------DGVVFIDPEYVKDRKVFG 96
            ::||||:|||||:::|||||||||||..|:||               ||||.:||||:|.||:|.
Human     2 SKVFKKTSSNGKLSIYLGKRDFVDHVDTVEPIGEFFLTKVLSVLLSTDGVVLVDPEYLKCRKLFV 66

  Fly    97 QVLAAFRYGREDLDVLGLTFRKDLYLAHEQIYP--PMQLDRPMTRLQERLIKKLGPNAHPFYFEV 159
            .:..||||||:||:|:|||||||||:...|:.|  ......|:|.|||||:.|||.||:||..::
Human    67 MLTCAFRYGRDDLEVIGLTFRKDLYVQTLQVVPAESSSPQGPLTVLQERLLHKLGDNAYPFTLQM 131

  Fly   160 PPYCPASVSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSI 224
            ....|.||:|||.|.|.||.||:|:|:|:|..||.|:...||:.|||.:|||.:||.:.|..||.
Human   132 VTNLPCSVTLQPGPEDAGKPCGIDFEVKSFCAENPEETVSKRDYVRLVVRKVQFAPPEAGPGPSA 196

  Fly   225 EVSKEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQY 289
            :..:.|::....:.|:|.:|:|:::|||.|||||.:.|.:|:.:||||:.|.|..|:.|:|..:|
Human   197 QTIRRFLLSAQPLQLQAWMDREVHYHGEPISVNVSINNCTNKVIKKIKISVDQITDVVLYSLDKY 261

  Fly   290 -KSVVAEIESEDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQ 353
             |:|..:..:|   .||...:.|:.|.:.|:||.:..|.||||||:||||||||||||:|.....
Human   262 TKTVFIQEFTE---TVAANSSFSQSFAVTPILAASCQKRGLALDGKLKHEDTNLASSTIIRPGMD 323

  Fly   354 RESLGIMVHYKVKVKLLISSPLLNGDLVA-----ELPFTLMHPKPEEEEHPLLGERSPRASLAGG 413
            :|.|||:|.|||:|.|::|...:.|||.|     |||..|:||||..|
Human   324 KELLGILVSYKVRVNLMVSCGGILGDLTASDVGVELPLVLIHPKPSHE----------------- 371

  Fly   414 GLPLVSMSDGETESATGGQDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAE 467
                                             .|..:||:.|:|.|   ||.|
Human   372 ---------------------------------AASSEDIVIEEFTR---KGEE 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	87/171 (51%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	75/165 (45%)
ARR3	XP_016885007.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.820