DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and arrb2a

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_009303544.1	Gene:	arrb2a / 321378	ZFINID:	ZDB-GENE-030131-29	Length:	414	Species:	Danio rerio

Alignment Length:	440	Identity:	253/440 - (57%)
Similarity:	315/440 - (71%)	Gaps:	42/440 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GDETGGDASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQ 97
            ||:.|         ||||||||.|.|:||||||||||||:.||||:|||:.:||||:||||||..
Zfish     2 GDKAG---------TRVFKKSSPNCKVTVYLGKRDFVDHLDHVDPVDGVILVDPEYLKDRKVFVT 57

  Fly    98 VLAAFRYGREDLDVLGLTFRKDLYLAHEQIYPPM-QLDRPMTRLQERLIKKLGPNAHPFYFEVPP 161
            :..||||||||||||||:||||||:...|.|||: :..:|.:||||||:||||.||:||:|.:|.
Zfish    58 LTCAFRYGREDLDVLGLSFRKDLYIFTFQAYPPIPEESKPHSRLQERLLKKLGQNAYPFHFSIPQ 122

  Fly   162 YCPASVSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEV 226
            ..|.||:|||.|.|.||:||||:|::||..:::|:|.||||||||.||||.|||.|.|.||.:|.
Zfish   123 NLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSMEEKNHKRNSVRLVIRKVQYAPEKPGPQPMVET 187

  Fly   227 SKEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKS 291
            ::.|:|....:||||:||||||:|||.|||||||.|||.:|||::|:.|||:||||||||||||.
Zfish   188 TRSFLMSDRSLHLEASLDKELYYHGEPISVNVHVTNNSTKTVKRVKISVRQYADICLFSTAQYKC 252

  Fly   292 VVAEIESEDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRES 356
            .||:||::|  |||...|..||:.|.|.|.||::|.||||||:||||||||||||::.:.:.:|.
Zfish   253 PVAQIEADD--QVASSSTFCKVYTLTPTLNNNREKRGLALDGKLKHEDTNLASSTIVKDVSNKEV 315

  Fly   357 LGIMVHYKVKVKLLIS-----SPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLP 416
            ||::|.|:|||||::|     |.||..|:..||||.||||||.|.
Zfish   316 LGVLVSYRVKVKLVVSRGGLLSSLLERDVSVELPFVLMHPKPSES-------------------- 360

  Fly   417 LVSMSDGETESATGGQDVPTTTNLIQLDDDE-AQDDDIIFEDFARLRLKG 465
              |:|  .:.||....|.|..||||:.|.:. ..||||:|||||||||||
Zfish   361 --SLS--HSTSAVPMLDPPIDTNLIEFDTNSLIPDDDIVFEDFARLRLKG 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	101/155 (65%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	100/164 (61%)
arrb2a	XP_009303544.1	Arrestin_N	19..175	CDD:278754	101/155 (65%)
arrb2a	XP_009303544.1	Arrestin_C	194..357	CDD:214976	100/164 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595700
Domainoid	1	1.000	223	1.000	Domainoid score	I2502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1381
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm25609
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870