DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and Arrb2

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_037043.1	Gene:	Arrb2 / 25388	RGDID:	2157	Length:	410	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	250/428 - (58%)
Similarity:	315/428 - (73%)	Gaps:	30/428 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGRED 108
            :..||||||||.|.|:||||||||||||:..|||:||||.:||:|:||||||..:..||||||||
  Rat     4 KPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGRED 68

  Fly   109 LDVLGLTFRKDLYLAHEQIYPPM-QLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPA 172
            ||||||:|||||::|..|.:||| ...||.||||:||:||||.:||||:|.:|...|.||:|||.
  Rat    69 LDVLGLSFRKDLFIATYQAFPPMPNPPRPPTRLQDRLLKKLGQHAHPFFFTIPQNLPCSVTLQPG 133

  Fly   173 PGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNK- 236
            |.|.||:||||:|::||..:::|:|.||||||||.||||.:||...|.|||.|.::.|:|...:
  Rat   134 PEDTGKACGVDFEIRAFCAKSIEEKSHKRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRS 198

  Fly   237 IHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDG 301
            :||||:||||||:|||.::|||||.|||.:|||||:|.|||:||||||||||||..||::|.:|
  Rat   199 LHLEASLDKELYYHGEPLNVNVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDD- 262

  Fly   302 CQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVK 366
             ||:|..|..||:.:.|||::|::|.|||||||||||||||||||::...|.:|.|||:|.|:||
  Rat   263 -QVSPSSTFCKVYTITPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVK 326

  Fly   367 VKLLISSPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESATGG 431
            |||::|.   .||:..||||.||||||  .:|..|    ||                 .:||...
  Rat   327 VKLVVSR---GGDVSVELPFVLMHPKP--HDHITL----PR-----------------PQSAPRE 365

  Fly   432 QDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAETE 469
            .|:|..||||:.|.:.|.||||:|||||||||||.:.:
  Rat   366 IDIPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDD 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	101/155 (65%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	99/160 (62%)
Arrb2	NP_037043.1	Arrestin_N	19..175	CDD:278754	101/155 (65%)
		Arrestin_C	199..350	CDD:214976	99/155 (64%)
		Interaction with TRAF6. /evidence=ECO:0000250	241..410		100/191 (52%)
		Interaction with AP2B1	378..410		17/26 (65%)
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250	386..396		8/9 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353565
Domainoid	1	1.000	226	1.000	Domainoid score	I2433
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1337
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm45036
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	LDO	PTHR11792
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770