DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and Sag

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_033144.1	Gene:	Sag / 20215	MGIID:	98227	Length:	403	Species:	Mus musculus

Alignment Length:	429	Identity:	199/429 - (46%)
Similarity:	269/429 - (62%)	Gaps:	57/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRYGREDLDVLG 113
            :|||.|.:..:|:||||||:||||:.|:|:||||.:|||.||.:||:..:..|||||:||:||:|
Mouse    13 IFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDGVVLVDPELVKGKKVYVTLTCAFRYGQEDIDVMG 77

  Fly   114 LTFRKDLYLAHEQIYPPMQLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSLQPAPGDVGK 178
            ||||:|||.:..|:|||:.....:|:|||.|:||||.|.:||....|.|.|.||.|||||.||||
Mouse    78 LTFRRDLYFSRVQVYPPVGAMSVLTQLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGK 142

  Fly   179 SCGVDYELKAF---VGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMKPNKIHLE 240
            |||||:|:|||   :.:..|||..|::||||.||||.:||.::|.|||.|.|.:|.|....::|.
Mouse   143 SCGVDFEVKAFASDITDPEEDKIPKKSSVRLLIRKVQHAPPEMGPQPSAEASWQFFMSDKPLNLS 207

  Fly   241 ATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIESEDGCQVA 305
            .:|.||:|.|||.|.|.|.|.||:::.||||||.|.|.|::.|:|:..|...||..|:::  :|.
Mouse   208 VSLSKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQE--KVQ 270

  Fly   306 PGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHYKVKVKLL 370
            |..||:|...|.||||||:::.|:||||::|||||||||||:|.....|..:||:|.|.:||||.
Mouse   271 PNSTLTKTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKLT 335

  Fly   371 IS---SPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSDGETESATGGQ 432
            :|   ..|.:.::..|:||.||||:||                           |...||
Mouse   336 VSGFLGELTSSEVATEVPFRLMHPQPE---------------------------DPAKES----- 368

  Fly   433 DVPTTTNLIQLDDDEAQDDDIIFEDFARLRLK--GAETE 469
                           .||::::||:|||..||  |..||
Mouse   369 ---------------VQDENLVFEEFARQNLKDTGENTE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	92/157 (59%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	76/162 (47%)
Sag	NP_033144.1	Interaction with RHO. /evidence=ECO:0000269\|PubMed:28753425	11..19		3/5 (60%)
		Arrestin_N	23..181	CDD:334019	92/157 (59%)
		Arrestin_C	200..361	CDD:214976	76/162 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..403		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.810