DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krz and arr-1

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_508183.1	Gene:	arr-1 / 180446	WormBaseID:	WBGene00000195	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	254/439 - (57%)
Similarity:	310/439 - (70%)	Gaps:	35/439 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKD-RKVFGQVLAAFRYGR 106
            ::..||||||:|.|||||.|||||||:|...:||.|||:|.||.||:|| |||...:||||||||
Worm     6 KKSGTRVFKKTSPNGKITTYLGKRDFIDRGDYVDLIDGMVLIDEEYIKDNRKVTAHLLAAFRYGR 70

  Fly   107 EDLDVLGLTFRKDLYLAHEQIYP--PMQLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVSL 169
            ||||||||||||||.....|:||  ...:.||::||||||.:|||.||.||:|||.|...:||:|
Worm    71 EDLDVLGLTFRKDLISETFQVYPQTDKSISRPLSRLQERLKRKLGANAFPFWFEVAPKSASSVTL 135

  Fly   170 QPAPGDVGKSCGVDYELKAFV----GENVEDKPHK---RNSVRLTIRKVMYAPSKVGEQPSIEVS 227
            ||||||.||.||||||||.||    |.:.| ||.|   .|:|||.|||:.|||.:...||.::||
Worm   136 QPAPGDTGKPCGVDYELKTFVAVTDGSSGE-KPKKSALSNTVRLAIRKLTYAPFESRPQPMVDVS 199

  Fly   228 KEFMMKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSV 292
            |.|||....:|:|.:||||:|:|||.||||||:.||||:||||:|:.:.|.||||||:||.|...
Worm   200 KYFMMSSGLLHMEVSLDKEMYYHGESISVNVHIQNNSNKTVKKLKIYIIQVADICLFTTASYSCE 264

  Fly   293 VAEIESEDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESL 357
            ||.|||.:|..|.||.||||||.:||||:|||||.|||||||||||||||||||::.:...:|||
Worm   265 VARIESNEGFPVGPGGTLSKVFAVCPLLSNNKDKRGLALDGQLKHEDTNLASSTILDSKTSKESL 329

  Fly   358 GIMVHYKVKVKLLISSPLLNGDLVAELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMSD 422
            ||:|.|:|||:.::..  |||:|.|||||||.|.||.|..     ||:.|      |||.:
Worm   330 GIVVQYRVKVRAVLGP--LNGELFAELPFTLTHSKPPESP-----ERTDR------GLPSI---- 377

  Fly   423 GETESATGGQDVPTTTNLIQLDD--DEAQDDDIIFEDFARLRLKGAETE 469
                .||.|.: |...:||||.:  :...|||:|||||||:||.|.::|
Worm   378 ----EATNGSE-PVDIDLIQLHEELEPRYDDDLIFEDFARMRLHGNDSE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	102/164 (62%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	100/159 (63%)
arr-1	NP_508183.1	Arrestin_N	22..186	CDD:278754	102/164 (62%)
arr-1	NP_508183.1	Arrestin_C	205..363	CDD:214976	100/159 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167104
Domainoid	1	1.000	208	1.000	Domainoid score	I1674
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2981
Inparanoid	1	1.050	458	1.000	Inparanoid score	I883
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S2648
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		oto18430
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	LDO	PTHR11792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2409
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750