DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and Arrb1

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_006507261.1	Gene:	Arrb1 / 109689	MGIID:	99473	Length:	455	Species:	Mus musculus

Alignment Length:	438	Identity:	261/438 - (59%)
Similarity:	318/438 - (72%)	Gaps:	38/438 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GDASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAF 102
            |....|:|..|||||:|.|||:||||||||||||:..|||:||||.:||||:|:|:|:..:..||
Mouse    34 GCVDGRQQQGRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAF 98

  Fly   103 RYGREDLDVLGLTFRKDLYLAHEQIYPPMQLD-RPMTRLQERLIKKLGPNAHPFYFEVPPYCPAS 166
            ||||||||||||||||||::|:.|.:||...| :|:||||||||||||.:|.||.||:||..|.|
Mouse    99 RYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHACPFTFEIPPNLPCS 163

  Fly   167 VSLQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFM 231
            |:|||.|.|.||:||||||:|||..||:|:|.||||||||.||||.|||.:.|.||:.|.:::|:
Mouse   164 VTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFL 228

  Fly   232 MKPNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEI 296
            |....:||||:||||:|:|||.|||||||.||:|:||||||:.|||:||||||:|||||..||..
Mouse   229 MSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAME 293

  Fly   297 ESEDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMV 361
            |::|  .|||..|..||:.|.|.||||::|.||||||:|||||||||||||:...|.||.|||:|
Mouse   294 EADD--NVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIV 356

  Fly   362 HYKVKVKLLISSPLLNGDLVA-----ELPFTLMHPKPEEEEHPLLGERSPRASLAGGGLPLVSMS 421
            .|||||||::|...|.|||.:     |||||||||||:||.                  |...:.
Mouse   357 SYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP------------------PHREVP 403

  Fly   422 DGETESATGGQDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAETE 469
            :.||         |..||||:||   ..||||:||||||.||||.:.:
Mouse   404 ESET---------PVDTNLIELD---TNDDDIVFEDFARQRLKGMKDD 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	106/155 (68%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	106/164 (65%)
Arrb1	XP_006507261.1	Arrestin_N	55..211	CDD:334019	106/155 (68%)
Arrb1	XP_006507261.1	Arrestin_C	230..393	CDD:214976	106/164 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849888
Domainoid	1	1.000	224	1.000	Domainoid score	I2548
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2981
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1387
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm42971
orthoMCL	1	0.900	-	-		OOG6_104809
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2409
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800