DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krz and arrb2

DIOPT Version :9

Sequence 1:	NP_001247400.1	Gene:	krz / 53554	FlyBaseID:	FBgn0040206	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_031753380.1	Gene:	arrb2 / 100101741	XenbaseID:	XB-GENE-481084	Length:	426	Species:	Xenopus tropicalis

Alignment Length:	432	Identity:	251/432 - (58%)
Similarity:	313/432 - (72%)	Gaps:	33/432 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ASSRRQATRVFKKSSSNGKITVYLGKRDFVDHVTHVDPIDGVVFIDPEYVKDRKVFGQVLAAFRY 104
            |::|..|.|||||||.|.|:||||||||||||:..|||:||||.:|.:|:|||||:..:..||||
Frog    18 ANARGAAVRVFKKSSPNCKLTVYLGKRDFVDHLDRVDPVDGVVLVDTDYLKDRKVYVTLTCAFRY 82

  Fly   105 GREDLDVLGLTFRKDLYLAHEQIYPPM-QLDRPMTRLQERLIKKLGPNAHPFYFEVPPYCPASVS 168
            ||||||||||:|||||:::..|.|||: :..:|:||||||||||||..||||:|.:|...|.||:
Frog    83 GREDLDVLGLSFRKDLFISKFQAYPPLPEEKKPLTRLQERLIKKLGEQAHPFFFTIPQNLPCSVT 147

  Fly   169 LQPAPGDVGKSCGVDYELKAFVGENVEDKPHKRNSVRLTIRKVMYAPSKVGEQPSIEVSKEFMMK 233
            |||.|.|.||:||||||::||..:.:|:|.||||||||.||||.:||.|.|.||..|.::.|:|.
Frog   148 LQPGPEDTGKACGVDYEIRAFCAKTMEEKMHKRNSVRLVIRKVQFAPEKPGPQPVAETTRHFLMS 212

  Fly   234 PNKIHLEATLDKELYHHGEKISVNVHVANNSNRTVKKIKVCVRQFADICLFSTAQYKSVVAEIES 298
            ...:||||:||||||:|||.|:|||||.|||::|||::||.|||:||||||||||||..||:||.
Frog   213 DRSLHLEASLDKELYYHGEPINVNVHVTNNSSKTVKRVKVSVRQYADICLFSTAQYKCPVAQIEQ 277

  Fly   299 EDGCQVAPGFTLSKVFELCPLLANNKDKWGLALDGQLKHEDTNLASSTLITNPAQRESLGIMVHY 363
            :|  ||.|..|..||:.|.|||:||::|.||||||:||||||||||||::...:.:|.|||:|.|
Frog   278 DD--QVTPSSTFCKVYTLTPLLSNNREKRGLALDGKLKHEDTNLASSTIVKEGSSKEVLGILVSY 340

  Fly   364 KVKVKLLISSPLLNGDLVAELPFTLMHPKPEEE-EHPLLGERSPRASLAGGGLPLVSMSDGETES 427
            :|||||::|.   .||:..||||.||||||.|. ..||  ...|:.
Frog   341 RVKVKLVVSR---GGDVAVELPFVLMHPKPPENISRPL--SEYPQT------------------- 381

  Fly   428 ATGGQDVPTTTNLIQLDDDEAQDDDIIFEDFARLRLKGAETE 469
                 |.|..||||:.|.:.||||||:|||||||||||.:.:
Frog   382 -----DAPVDTNLIEFDTNFAQDDDIVFEDFARLRLKGLKDD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krz	NP_001247400.1	Arrestin_N	59..214	CDD:419887	100/155 (65%)
krz	NP_001247400.1	Arrestin_C	233..393	CDD:214976	100/159 (63%)
arrb2	XP_031753380.1	Arrestin_N	37..193	CDD:395268	100/155 (65%)
arrb2	XP_031753380.1	Arrestin_C	212..367	CDD:214976	100/159 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1402
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	1	1.000	-	-		FOG0000854
OrthoInspector	1	1.000	-	-		otm48094
Panther	1	1.100	-	-	LDO	PTHR11792
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X758
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160