DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Ca and CLEC4A

DIOPT Version :9

Sequence 1:	NP_652642.2	Gene:	lectin-21Ca / 53552	FlyBaseID:	FBgn0040107	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	166	Identity:	43/166 - (25%)
Similarity:	69/166 - (41%)	Gaps:	33/166 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ALSAKIKNVKNIQRHLASLELQLQETKKALNLSVE-AKKVMPKTE-----IPSQFQKIGWRHFFI 155
            |:|..|..|...|::  |..|:.:.||:.::.::| .||.||..|     .|..::......:||
Human    58 AISFFIAFVIFFQKY--SQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFI 120

  Fly   156 EKKHKVDWFKATSMCHKMGAHLLTIQSEDELDAIRTELKD-------INDGS---HDFWLDINDI 210
            ..: ...|..:...|.:|.||||.|.:::|.|.|...|::       ::|..   |..|:|
Human   121 STE-SASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVD---- 180

  Fly   211 AKWGEFISLATGMNPPFLKWHKHRPQVQIHQRCVHL 246
                     .|..|.....||...|. ..::|||.|
Human   181 ---------QTPYNESSTFWHPREPS-DPNERCVVL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Ca	NP_652642.2	CLECT	158..265	CDD:153057	25/99 (25%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	28/116 (24%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		0/1 (0%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		43/166 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010